Journal ArticleDOI
The anti-tumour effect of Klebsiella pneumoniae capsular polysaccharides.
TLDR
The polysaccharide isolated from the capsule of Klebsiella pneumoniae serotype K24 was found to suppress the proliferation of Ehrlich ascites tumour cells in vitro, but did not alter the cell cycle distribution of cells.Abstract:
K24 capsular polysaccharide (K24-CPS), with a known structure of a repeating unit, was isolated from the capsule of Klebsiella pneumoniae serotype K24. The polysaccharide was found to suppress the proliferation of Ehrlich ascites tumour (EAT) cells in vitro, but did not alter the cell cycle distribution of cells. K24-CPS treatment reduced the tyrosine phosphorylation of some proteins in EAT cells. Furthermore, the treatment also decreased the expression of c-JUN, but had no effect on the levels of c-FOS and c-MYC. It is speculated that the growth suppression effect of K24-CPS may be related to its effect in down-regulating c-JUN expression.read more
Citations
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Journal ArticleDOI
Polysaccharide biological response modifiers.
TL;DR: Among different exogeneous BRMs, polysaccharide BRMs have the widest occurrence in nature and have been tested for their therapeutic properties in human clinical trials.
Journal ArticleDOI
Preparation of a novel sulfated glycopeptide complex and inhibiting L1210 cell lines property in vitro
TL;DR: Anti-tumour test in vitro showed that both complexes have properties to inhibit growth of L1210 cell lines and have similar bioactivities, but might have different mechanism.
Journal ArticleDOI
Microbial utilization of the industrial wastewater pollutants 2-ethylhexylthioglycolic acid and iso -octylthioglycolic acid by aerobic Gram-negative bacteria
TL;DR: Industrial wastewater from the production of sulfur containing esters and the resulting products of this synthesis, EHTG and IOTG, were deployed in this study to enrich novel bacterial strains, since no wastewater and E HTG or IotG degrading microorganisms were hitherto described or available.
References
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AP-1 function and regulation.
TL;DR: This work has shown that regulation by heterodimerization between Jun, Fos and ATF proteins, AP-1 activity is regulated through interactions with specific protein kinases and a variety of transcriptional coactivators, and there has been considerable progress in understanding some of the mechanisms and signaling pathways involved in the regulation of AP.
Journal ArticleDOI
Mitogen-activated protein kinase pathways.
Megan Robinson,Melanie H. Cobb +1 more
TL;DR: Recent advances in the study of mitogen-activated protein kinase cascades include the cloning of genes encoding novel members of the cascades, further definition of the roles of the cascade in responses to extracellular signals, and examination of cross-talk between different cascades.
Journal ArticleDOI
Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast
TL;DR: Two new mammalian MAPK relatives, JNK1 and p38, are identified, and the pathways which are responsible for their activation are identified.
Journal ArticleDOI
Heparin increases the affinity of basic fibroblast growth factor for its receptor but is not required for binding.
Monireh Roghani,Alka Mansukhani,Patrizia Dell'Era,Paola Bellosta,Claudio Basilico,Daniel B. Rifkin,David Moscatelli +6 more
TL;DR: Heparin or heparan sulfate is not required for the binding of bFGF to its receptors but increases the binding affinity to a moderate degree, and the requirement for heparin in signal transduction through the receptor was investigated.
Journal ArticleDOI
The level of intracellular glutathione is a key regulator for the induction of stress-activated signal transduction pathways including Jun N-terminal protein kinases and p38 kinase by alkylating agents.
TL;DR: The intracellular glutathione (GSH) level is identified as critical for JNK/SAPK activation by MMS: enhancing the GSH level by pretreatment of the cells with GSH or N-acetylcysteine inhibits, whereas depletion of the cellular GSH pool causes hyperinduction of JNK/.