Journal ArticleDOI
The biology of hernias and the abdominal wall
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TLDR
It is evident that an improved understanding of structural tissue matrix biology will lead to improved results following abdominal wall reconstructions, and it may be that hernia formation is a heterogeneous disease, not unlike cancer, where one population of patients express an extracellular matrix defect leading to primary hernia disease.Abstract:
The fundamental mechanism for hernia formation is loss of the mechanical integrity of abdominal wall structural tissue that results in the inability to offset and contain intra-abdominal forces during valsalva and loading of the torso. There is evidence that genetic or systemic extracellular matrix disorders may predispose patients to hernia formation. There is also evidence that acute laparotomy wound failure leads to hernia formation and increases the risk of recurrent hernia disease. It may be that hernia formation is a heterogeneous disease, not unlike cancer, where one population of patients express an extracellular matrix defect leading to primary hernia disease, while other subsets of patients acquire a defective, chronic wound phenotype following failed laparotomy and hernia repairs. It is evident that an improved understanding of structural tissue matrix biology will lead to improved results following abdominal wall reconstructions.read more
Citations
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Journal ArticleDOI
Incisional ventral hernias: Review of the literature and recommendations regarding the grading and technique of repair
Karl H. Breuing,Charles E. Butler,Stephen J. Ferzoco,Michael G. Franz,Charles Scott Hultman,Joshua F. Kilbridge,Michael J. Rosen,Ronald P. Silverman,Daniel Vargo +8 more
TL;DR: A novel hernia grading system based on risk factor characteristics of the patient and the wound is proposed so that surgeons may better assess each patient's risk for surgical-site occurrences and thereby select the appropriate surgical technique, repair material, and overall clinical approach for the patient.
Journal ArticleDOI
Incidence of and risk factors for incisional hernia after abdominal surgery
Keita Itatsu,Yukihiro Yokoyama,Gen Sugawara,H. Kubota,Y. Tojima,Yasuhiro Kurumiya,H. Kono,H. Yamamoto,Masahiko Ando,Masato Nagino +9 more
TL;DR: A small number of studies have estimated the incidence of incisional hernia after abdominal surgery, but these studies are small in comparison with the need to investigate further the cause of hernia.
Journal ArticleDOI
Connective tissue alteration in abdominal wall hernia
TL;DR: The aim of this study was to review the literature on specific collagen alterations in abdominal wall hernia formation to assess the need for further research into these mechanisms.
Journal ArticleDOI
Randomized clinical trial comparing polypropylene or polydioxanone for midline abdominal wall closure.
TL;DR: This prospective randomized trial compared suture materials for closure of the fascia after abdominal surgery forcisional hernia patients with high incisional pain.
Journal ArticleDOI
A review on biological and biomimetic materials and their applications
N. Suresh Kumar,R. Padma Suvarna,K. Chandra Babu Naidu,Prasun Banerjee,A. Ratnamala,H. Manjunatha +5 more
TL;DR: Recently, an extensive research has been going on to introduce a wide variety of biomimetic materials which can exhibit advanced properties as mentioned in this paper, such as Se-modified carbon nitride nanosheets, small intestinal submucosa, magnesium-strontium hydroxyapatite, dimethylglyoxime and polydimethylsiloxane, Ag/Ag@AgCl/ZnO and PDTC(COOH)4/HA.
References
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Book
The Molecular and Cellular Biology of Wound Repair
Richard A.F. Clark,P. M. Henson +1 more
TL;DR: Wound Repair: Overview and General Considerations (R.A.F. Clark), Macrophage Involvement in Wound Repair, Remodeling and Fibrosis, and the Role of Plateletderived Growth Factor in vivo (C.W. Riches).
Journal ArticleDOI
A Comparison of Suture Repair with Mesh Repair for Incisional Hernia
R W Luijendijk,Wim C. J. Hop,van den Tol Mp,de Lange Dc,Braaksma Mm,Jan N. M. IJzermans,Boelhouwer Ru,de Vries Bc,Salu Mk,Wereldsma Jc,Bruijninckx Cm,J. Jeekel +11 more
TL;DR: Among patients with midline abdominal incisional hernias, mesh repair is superior to suture repair with regard to the recurrence of hernia, regardless of the size of the hernia.
Journal ArticleDOI
Incisional hernia: A 10 year prospective study of incidence and attitudes
Marjorie Mudge,L. E. Hughes +1 more
TL;DR: Recurrence is common after surgical repair but seems to be related to surgical technique, and the possibility of complications occurring from an incisional hernia does not appear to be discussed with patients although obstruction occurred in 14 per cent of patients with troublesome hernia.
Journal ArticleDOI
Mechanotransduction and the functional response of bone to mechanical strain
TL;DR: Mechanotransduction plays a crucial role in the physiology of many tissues including bone and some hormones may interact with local mechanical signals to change the sensitivity of the sensor or effector cells to mechanical load.