Journal ArticleDOI
The combination of randomized and historical controls in clinical trials.
Reads0
Chats0
TLDR
It is current practice in clinical trials to rely exclusively on either randomized controls or historical controls, but not both, and the methods described provide an objective, quantitative approach for the combination of these two sources of control data and this should lead to a more efficient use of patients in the execution of clinical trials.About:
This article is published in Journal of Chronic Diseases.The article was published on 1976-03-01. It has received 384 citations till now. The article focuses on the topics: Randomized controlled trial.read more
Citations
More filters
Book
Bayesian approaches to clinical trials and health-care evaluation
TL;DR: In this paper, the authors present a survey of Bayesian methods for health-care evaluation, focusing on the following: 1.1 What is probability? 2.2 Random variables, parameters and likelihood.
Journal ArticleDOI
A Stage Model of Behavioral Therapies Research: Getting Started and Moving on From Stage I
TL;DR: A Stage Model of Behavioral Therapies research as mentioned in this paper, by articulating the progressive stages of development and evaluation for behavioral treatments, recognizes the scientific merit and need for support for treatment development and initial evaluation designated as stage I.
BookDOI
Bayesian Approaches to Clinical Trials and Health-Care Evaluation: Spiegelhalter/Clinical Trials and Health-Care Evaluation
TL;DR: Bayesian Approaches to Clinical Trials and Health-Care Evaluation provides a valuable overview of this rapidly evolving field, including basic Bayesian ideas, prior distributions, clinical trials, observational studies, evidence synthesis and cost-effectiveness analysis.
Journal ArticleDOI
A randomized, double-blind, futility clinical trial of creatine and minocycline in early Parkinson disease.
TL;DR: Both creatine and minocycline should be considered for definitive Phase III trials to determine if they alter the long term progression of Parkinson disease (PD).
Journal ArticleDOI
Bayesian methods in health technology assessment: a review.
TL;DR: A full structured review of applications of Bayesian methods to randomised controlled trials, observational studies, and the synthesis of evidence, in a form which should be reasonably straightforward to update is provided.
References
More filters
Journal ArticleDOI
Non-randomized controls in cancer clinical trials.
TL;DR: Quantitative, comparative clinical trials can sometimes be better accomplished with technics other than randomization for selection of a control group, including selection of literature controls, matched controls and controls from a previous study.
Journal ArticleDOI
Controlled studies in clinical cancer research.
TL;DR: A review of abstracts and papers reporting clinical trials of new anticancer agents reveals that only a small percentage have been controlled, suggesting that continued development of the study-design process and new uses of peer review are needed.