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The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor
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TLDR
Cells from some tumors use an altered metabolic pattern compared with that of normal differentiated adult cells in the body, which provides substrates for cell growth and division and free energy (ATP) from enhanced glucose use.Abstract:
Cells from some tumors use an altered metabolic pattern compared with that of normal differentiated adult cells in the body. Tumor cells take up much more glucose and mainly process it through aerobic glycolysis, producing large quantities of secreted lactate with a lower use of oxidative phosphorylation that would generate more adenosine triphosphate (ATP), water, and carbon dioxide. This is the Warburg effect, which provides substrates for cell growth and division and free energy (ATP) from enhanced glucose use. This metabolic switch places the emphasis on producing intermediates for cell growth and division, and it is regulated by both oncogenes and tumor suppressor genes in a number of key cancer-producing pathways. Blocking these metabolic pathways or restoring these altered pathways could lead to a new approach in cancer treatments.read more
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Dynamics of resource allocation in Biological Systems II: On cancer cell metabolism
TL;DR: Aerobic glycolysis (Warburg effect) is examined, the metabolic phenomenon of cells utilizing glucose fermentation to lactate even under conditions of ample oxygen availability, and cancer-related processes are considered, to consider resource reallocations between processes of two hypothetical cells.
Emerging Role of Mitochondria as A Regulator of Cellular Metabolism and Executor of Apoptosis- A Promising Target for Anti-Cancer Drug Development
TL;DR: This review tries to abbreviates the interconnections between regulatory role of mitochondria in cellular metabolism and apoptosis in terms of mutations of mitochondrial DNA (mt-DNA), altered gene expression for mitochondrial complex, morphological rearrangements of mitochondrialria, post-translational regulation of mitochondrial protein and their actions and oncogenes and oncosuppressors.
Role of the Cytoplasmic Polyadenylation Element Binding Proteins in Neuron: A Dissertation
TL;DR: Using nanofiltration membranes for the recovery of phosphorous with a second type of technology for the Recovery of nitrogen is suggest to be a viable process and the process is described in more detail in the next chapter.
Prediction of Cancer Phenotypes Through Machine Learning Approaches: From Gene Modularity to Deep Neural Networks
TL;DR: Deep Pharmacogenomic Modules (Deep-PGMs), a framework to predict drug response outcomes for tumor samples using drug features and gene expression data, is introduced and it is demonstrated that this framework outperforms traditional machine learning approaches that do not take advantage of the modular structure of geneexpression data sets.
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Screening and identification of potential prognostic biomarkers in bladder urothelial carcinoma: Evidence from bioinformatics analysis
TL;DR: Mechanisms underlying the control of BLCA molecular signatures by TFs and miRNAs which their alteration reduce the chance of survival rate in B LCA are highlighted.
References
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TL;DR: It is proposed that the metabolism of cancer cells, and indeed all proliferating cells, is adapted to facilitate the uptake and incorporation of nutrients into the biomass needed to produce a new cell.
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Targeting HIF-1 for cancer therapy
TL;DR: Hypoxia-inducible factor 1 (HIF-1) activates the transcription of genes that are involved in crucial aspects of cancer biology, including angiogenesis, cell survival, glucose metabolism and invasion.
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An Integrated Genomic Analysis of Human Glioblastoma Multiforme
D. Williams Parsons,Siân Jones,Xiaosong Zhang,Jimmy Lin,Rebecca J. Leary,Philipp Angenendt,Parminder Mankoo,Hannah Carter,I-Mei Siu,Gary L. Gallia,Alessandro Olivi,Roger E. McLendon,B.K. Ahmed Rasheed,Stephen T. Keir,Tatiana Nikolskaya,Yuri Nikolsky,Dana A. Busam,Hanna Tekleab,Luis A. Diaz,James Hartigan,Doug R. Smith,Robert L. Strausberg,Suely Kazue Nagahashi Marie,Sueli Mieko Oba Shinjo,Hai Yan,Gregory J. Riggins,Darell D. Bigner,Rachel Karchin,Nick Papadopoulos,Giovanni Parmigiani,Bert Vogelstein,Victor E. Velculescu,Kenneth W. Kinzler +32 more
TL;DR: Recurrent mutations in the active site of isocitrate dehydrogenase 1 (IDH1) occurred in a large fraction of young patients and in most patients with secondary GBMs and were associated with an increase in overall survival.
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IDH1 and IDH2 Mutations in Gliomas
Hai Yan,D. Williams Parsons,Genglin Jin,Roger E. McLendon,B.K. Ahmed Rasheed,Weishi Yuan,Ivan Kos,Ines Batinic-Haberle,Siân Jones,Gregory J. Riggins,Henry S. Friedman,Allan H. Friedman,David A. Reardon,James E. Herndon,Kenneth W. Kinzler,Victor E. Velculescu,Bert Vogelstein,Darell D. Bigner +17 more
TL;DR: Mutations of NADP(+)-dependent isocitrate dehydrogenases encoded by IDH1 and IDH2 occur in a majority of several types of malignant gliomas.