D
Doug R. Smith
Researcher at Beckman Coulter
Publications - 4
Citations - 6551
Doug R. Smith is an academic researcher from Beckman Coulter. The author has contributed to research in topics: Neanderthal genome project & Neanderthal. The author has an hindex of 4, co-authored 4 publications receiving 6087 citations. Previous affiliations of Doug R. Smith include United States Department of Energy.
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Journal ArticleDOI
An Integrated Genomic Analysis of Human Glioblastoma Multiforme
D. Williams Parsons,Siân Jones,Xiaosong Zhang,Jimmy Lin,Rebecca J. Leary,Philipp Angenendt,Parminder Mankoo,Hannah Carter,I-Mei Siu,Gary L. Gallia,Alessandro Olivi,Roger E. McLendon,B.K. Ahmed Rasheed,Stephen T. Keir,Tatiana Nikolskaya,Yuri Nikolsky,Dana A. Busam,Hanna Tekleab,Luis A. Diaz,James Hartigan,Doug R. Smith,Robert L. Strausberg,Suely Kazue Nagahashi Marie,Sueli Mieko Oba Shinjo,Hai Yan,Gregory J. Riggins,Darell D. Bigner,Rachel Karchin,Nick Papadopoulos,Giovanni Parmigiani,Bert Vogelstein,Victor E. Velculescu,Kenneth W. Kinzler +32 more
TL;DR: Recurrent mutations in the active site of isocitrate dehydrogenase 1 (IDH1) occurred in a large fraction of young patients and in most patients with secondary GBMs and were associated with an increase in overall survival.
Journal ArticleDOI
The Genetic Landscape of the Childhood Cancer Medulloblastoma
D. Williams Parsons,D. Williams Parsons,Meng Li,Xiaosong Zhang,Siân Jones,Rebecca J. Leary,Jimmy Lin,Simina M. Boca,Hannah Carter,Josue Samayoa,Chetan Bettegowda,Chetan Bettegowda,Gary L. Gallia,George I. Jallo,Zev A. Binder,Yuri Nikolsky,James Hartigan,Doug R. Smith,Daniela S. Gerhard,Daniel W. Fults,Scott R. VandenBerg,Mitchel S. Berger,Suely Kazue Nagahashi Marie,Sueli Mieko Oba Shinjo,Carlos Clara,Peter C. Phillips,Jane E. Minturn,Jaclyn A. Biegel,Alexander R. Judkins,Adam C. Resnick,Phillip B. Storm,Tom Curran,Yiping He,B.K. Ahmed Rasheed,Henry S. Friedman,Stephen T. Keir,Roger E. McLendon,Paul A. Northcott,Michael D. Taylor,Peter C. Burger,Gregory J. Riggins,Gregory J. Riggins,Rachel Karchin,Giovanni Parmigiani,Darell D. Bigner,Hai Yan,Nick Papadopoulos,Bert Vogelstein,Kenneth W. Kinzler,Victor E. Velculescu +49 more
TL;DR: Key differences between the genetic landscapes of adult and childhood cancers are demonstrated, dysregulation of developmental pathways as an important mechanism underlying MBs is highlighted, and a role for a specific type of histone methylation in human tumorigenesis is identified.
Journal ArticleDOI
Sequencing and analysis of Neanderthal genomic DNA
James P. Noonan,James P. Noonan,Graham Coop,Sridhar Kudaravalli,Doug R. Smith,Johannes Krause,Joe Alessi,Feng Chen,Darren Platt,Svante Pääbo,Jonathan K. Pritchard,Edward M. Rubin,Edward M. Rubin +12 more
TL;DR: The characterization of Neanderthals from a new perspective is described, based on the development of a Neanderthal metagenomic library and its high-throughput sequencing and analysis, and the finding that the Neanderthal and human genomes are at least 99.5% identical is found.
Sequencing and Analysis of
James P. Noonan,Graham Coop,Sridhar Kudaravalli,Doug R. Smith,Johannes Krause,Joe Alessi,Feng Chen,Darren Platt,Svante Pääbo,Jonathan K. Pritchard,Edward M. Rubin +10 more
TL;DR: This initial analysis of the Neanderthal genome advances understanding of the evolutionary relationship of Homo sapiens and Homo neanderthalensis and signifies the dawn of Neanderthal genomics.