Journal ArticleDOI
The distribution of collagen in human articular cartilage with some of its physiological implications.
TLDR
Serial slices of articular cartilage obtained at necropsy from apparently normal femoral condyles of individuals between the ages of twenty-six and sixty were examined chemically, by electron microscopy and for permeability, demonstrating clearly the close relation between the physical properties of cartilage and its chemical composition.Abstract:
1. Serial slices of articular cartilage obtained at necropsy from apparently normal femoral condyles of individuals between the ages of twenty-six and sixty were examined chemically, by electron microscopy and for permeability. 2. The most superficial layer was shown by chemical analysis and electron microscopy to have the highest collagen content, which fell sharply with distance from the articular surface. On the other hand the glycosaminoglycan content was very low in the superficial layers but increased with depth. This variation was found in all specimens tested but the absolute levels of collagen and of glycosaminoglycans were widely different. There was no correlation of chemical composition with age. 3. Collagen fibrils in the superficial layer were of much smaller diameter than in the deeper zones. 4. Hydraulic permeability was shown to depend more on glycosaminoglycan than on collagen content, although it varied inversely with both these factors. 5. The results obtained demonstrate clearly the close relation between the physical properties of cartilage and its chemical composition.read more
Citations
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Journal ArticleDOI
Fluid transport and mechanical properties of articular cartilage: A review
TL;DR: This review is aimed at unifying the understanding of cartilage viscoelastic properties in compression, in particular the role of compression-dependent permeability in controlling interstitial fluid flow and its contribution to the observed vis coelastic effects.
Journal ArticleDOI
Collagen tissue engineering: development of novel biomaterials and applications.
TL;DR: The complex scenario of collagen characteristics, types, fibril arrangement, and collagen structure-related functions (in a variety of connective tissues including bone, cartilage, tendon, skin and cornea) are addressed in this review.
Journal ArticleDOI
Cartilage MRI T2 relaxation time mapping: overview and applications.
TL;DR: In vivo cartilage T2 mapping can improve understanding of arthritis, cartilage aging, and response of cartilage to exercise and help to develop new pharmaceuticals and surgical techniques for preserving cartilage.
Journal ArticleDOI
The role of the cartilage matrix in osteoarthritis
Dick Heinegård,Tore Saxne +1 more
TL;DR: The role of bone has not been fully elucidated, but changes in bone seem to be secondary to alterations in articular cartilage, which change the mechanical environment of the bone cells and induce them, in turn, to modulate tissue structure.
Journal ArticleDOI
Mechano-electrochemical properties of articular cartilage: their inhomogeneities and anisotropies.
Van C. Mow,X. Edward Guo +1 more
TL;DR: In this paper, the recent advances in cartilage biomechanics and electromechanics are reviewed and summarized, focusing on the new experimental and theoretical findings of cartilage mechanics.
References
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Form und Bau der Gelenkknorpel in ihren Beziehungen zur Funktion
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Physicochemical Properties of Cartilage in the Light of Ion Exchange Theory
TL;DR: The concentration of fixed negatively-charged groups in cartilage was shown to be the most important parameter and fixed charge density was found to increase with distance from the articular surface and this variation was reflected in the other properties.
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The correlation of fixed negative charge with glycosaminoglycan content of human articular cartilage
TL;DR: In the 25–60 age group neither the hexuronic acid nor the total hexosamine contents showed any correlation with the age of the subject, however, there was considerable local variation and variation between individuals.