Journal ArticleDOI
The effect of 5,8,11,14-eicosatetraynoic acid on lipid metabolism.
L. D. Tobias,James G. Hamilton +1 more
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TLDR
The effects of ETYA on inflammation, platelet aggregation and tumor growth are discussed, keeping in mind the relevance of arachidonate metabolism to these processes.Abstract:
The purpose of this presentation is to review the current state of knowledge regarding 5,8,11,14-eicosatetraynoic acid (ETYA, Ro 3-1428) and its effects on lipid metabolism. Accordingly, the topics discussed include hypocholesterolemic and dermatological studies involving ETYA in both animals and man, as well as the effects of ETYA on desaturate enzymes. Metabolic studies involving ETYA are also noted. Primary interest is focused on the effects of ETYA on selected processes of arachidonate metabolism, and the effect of ETYA on inflammation, platelet aggregation and tumor growth are discussed, keeping in mind the relevance of arachidonate metabolism to these processes.read more
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Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers.
Hansjörg Keller,Christine Dreyer,Jeffrey A. Medin,Abderrahim Mahfoudi,Keiko Ozato,Walter Wahli +5 more
TL;DR: The data demonstrate a convergence of the PPAR and RXR signaling pathways in the regulation of the peroxisomal beta-oxidation of fatty acids by fatty acids and retinoids.
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Stratum Corneum Moisturization at the Molecular Level
Journal ArticleDOI
Direct regulation of ion channels by fatty acids
TL;DR: A variety of fatty acids regulate the activity of specific ion channels by mechanisms not involving the enzymatic pathways that convert arachidonic acid to oxygenated metabolites as mentioned in this paper, and these actions occur in patches of membrane excised from the cell and are not mediated by cellular signal transduction pathways that require soluble factors such as nucleotides and calcium.
Journal ArticleDOI
Suppression of voltage-gated L-type Ca2+ currents by polyunsaturated fatty acids in adult and neonatal rat ventricular myocytes
TL;DR: It is concluded that PUFAs may act as antiarrhythmic agents in vivo in normal and Ca2-overloaded cells principally because they reduce Ca2+ entry by blocking I(Ca,L).
Journal ArticleDOI
Arachidonic acid and other fatty acids directly activate potassium channels in smooth muscle cells.
TL;DR: Arachidonic acid, as well as fatty acids that are not substrates for cyclooxygenase and lipoxygenases enzymes, activated a specific type of potassium channel in freshly dissociated smooth muscle cells, and so may constitute a class of signal molecules that regulate ion channels.
References
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Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
TL;DR: Experiments with guinea-pig lung suggest that some of the therapeutic effects of sodium salicylate and aspirin-like drugs are due to inhibition of the synthesis of prostaglandins.
Journal ArticleDOI
Prostaglandin Endoperoxides. Novel Transformations of Arachidonic Acid in Human Platelets
Mats Hamberg,Bengt Samuelsson +1 more
TL;DR: The almost exclusive transformation of the endoperoxide structure into non-prostaglandin derivatives supports the hypothesis that the end operoxides can participate directly and not by way of the classical prostaglandins in regulation of cell functions.
Journal Article
Drugs which inhibit prostaglandin biosynthesis.
TL;DR: The participation of prostag landins in complex biological events may be investigated with the aid of substrate analogues or with pharmacological agents which block prostaglandin biosynthesis both in vitro and in vivo.
Journal ArticleDOI
On the Specificity of the Oxygenation of Unsaturated Fatty Acids Catalyzed by Soybean Lipoxidase
Mats Hamberg,Bengt Samuelsson +1 more
TL;DR: The conversion of [13l-3H, 3-14C]8,11,14-eicosatrienoic acid is accompanied by an isotope effect, suggesting that the hydrogen removal occurs as the initial step of the reaction, and only the hydrogen of the l configuration is removed by the enzyme during the conversion.
Journal ArticleDOI
Transformation of arachidonic acid and homo-gamma-linolenic acid by rabbit polymorphonuclear leukocytes. Monohydroxy acids from novel lipoxygenases.
TL;DR: Addition of arachidonic acid and homo-gamma-linolenic acid to a suspension of rabbit peritoneal neutrophils led to the synthesis of 5-L-hydroxy-6,8,11,14-eicosatetraenoic acid and 8- L-hydroxyl group alpha to a pair of conjugated cis/trans double bonds suggested that they were formed by action of lipoxygenease(s).
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