Journal ArticleDOI
The effect of ethanol on GABAergic transmission
TLDR
In this article, the triazolopyridazines, a new class of drugs, may be promising compounds for treatment of withdrawal with a more specific mode of action and fewer side effects.About:
This article is published in Neuroscience & Biobehavioral Reviews.The article was published on 1983-03-01. It has received 151 citations till now. The article focuses on the topics: GABAergic & GABAA receptor.read more
Citations
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Journal ArticleDOI
Addiction, a Disease of Compulsion and Drive: Involvement of the Orbitofrontal Cortex
Nora D. Volkow,Joanna S. Fowler +1 more
TL;DR: It is implied that pleasure per se is not enough to maintain compulsive drug administration in the drugaddicted subject and that drugs that could interfere with the activation of the striato-thalamo-orbitofrontal circuit could be beneficial in the treatment of drug addiction.
Journal ArticleDOI
A selective imidazobenzodiazepine antagonist of ethanol in the rat
Peter D. Suzdak,John R. Glowa,Jacqueline N. Crawley,Rochelle D. Schwartz,Phil Skolnick,Steven M. Paul +5 more
TL;DR: The identification of a selective benzodiazepine antagonist of ethanol-stimulated 36Cl- uptake in vitro that blocks the anxiolytic and intoxicating actions ofanol suggests that many of the neuropharmacologic actions of ethanol may be mediated via central GABA receptors.
Journal ArticleDOI
The neuropharmacological and neurochemical basis of place learning in the Morris water maze
TL;DR: The Morris water maze offers several advantages over other methods of studying the neurochemical basis of learning and memory, particularly with respect to its ability to dissociate deficits in memory formation from deficits in sensory, motor, motivational and retrieval processes.
Book ChapterDOI
Effects of ethanol on ion channels.
TL;DR: The diversity of ion channels subunits, their prominent role in brain function, and ethanol action are likely to make them important contributors to alcoholism and alcohol abuse.
Journal ArticleDOI
Ethanol withdrawal is associated with increased extracellular glutamate in the rat striatum
TL;DR: It is suggested that the increased extraneuronal glutamate reflects overactivity of excitatory neurotransmission during withdrawal, and provides a biochemical rationale for the use of NMDA receptor antagonists and ethanol itself in the treatment of ethanol withdrawal syndrome.
References
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Amino acid transmitters in the mammalian central nervous system
TL;DR: Evidence for A m i n o Acids as T ransmi t t e r s as well as evidence for Synthesis and Storage are presented.
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GABA‐Benzodiazepine‐Barbiturate Receptor Interactions
TL;DR: Evidence supports the model for a complex containing receptor sites for GABA, benzodiazepines, and picrotoxininl barbiturates, as well as the chloride ionophore, and thus the relevance of GABA to the actions of the other drugs.
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Induction of physical dependence upon ethanol and the associated behavioral changes in rats.
TL;DR: A rapid succession of two diverse clusters of signs and reactions represents a reversal of the central nervous system function from the extremes of ethanol intoxication to the extremesof ethanol dependence (CNS hyperexcitability) during the withdrawal period.
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GABAergic modulation of benzodiazepine binding site sensitivity.
TL;DR: GA can modulate the responsiveness of this BZ binding site since the addition of GABA to cortical membranes in vitro results in an increased affinity of the 3H-diazepam binding site for its ligand.
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Alcohol intoxication and withdrawal
TL;DR: Koch-Weser et al. as discussed by the authors described the three major problems of acute intoxication: intoxication itself, the withdrawal reactions that follow interruption of alcohol intake, and emotional problems in the post-withdrawal period that may lead to relapse into heavy drinking.