The effect of vitamin D on nonspecific low back pain
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TLDR
The goal of this study is to evaluate the effect of vitamin D3 administration on improvements in CLBP.Abstract:
Background
Nonspecific low back pain is known as one of the most common reasons for chronic low back pain (CLBP) that burdens healthcare systems with high costs. According to a hypothesis, CLBP has been associated with vitamin D3 deficiency, the goal of this study is to evaluate the effect of vitamin D3 administration on improvements in CLBP.
Materials and Methods
This double blind randomized clinical trial included 53 patients aged between 18–40 years with nonspecific CLBP. Pain was measured using the pain visual analogue scale score (VAS), and serum 25-OH-vitamin D level was measured using an enzyme-linked immunosorbent assay kit. The patients were randomly divided into two groups based on sex and weight. Pearl of vitamin D3 (50 000 IU) or placebo was administered orally every week for 8 weeks. Data were analyzed via SPSS 17th edition software using two-tailed paired t-test and chi-square test.
Results
There were 26 and 27 patients in drug and placebo groups respectively. Out of 53 subjects, 75.47% were female. There was no statistically significant difference in the mean age, sex, and mean weight between the two groups. The mean serum 25-OH-vitamin D level was 18.86 ± 9.24 nmol/L on the first visit. After 8 weeks of intervention, the mean serum 25-OH-vitamin D level changed from 17.88 ± 9.04 to 27.52 ± 9.04 (P = 0.043) and from 19.81 ± 9.60 to 18.91 ± 7.84 (P = 0.248) in drug and placebo groups, respectively. The mean VAS score for pain decreased from 5.42 ± 1.65 to 3.03 ± 3.14 (P = 0.001) and from 6.42 ± 1.62 to 3.11 ± 3.08 (P = 0.001) among drug and placebo groups, respectively. The mean changes in chronic pain were 2.38 ± 2.62, 95% confidence interval (CI) = 1.32–3.44 in the drug group and 3.33 ± 3.67, 95%CI = 0.61–2.55 in the placebo group. No significant statistical difference between the two groups was observed.
Conclusion
According to our results, both vitamin D3 and placebo treatments improved CLBP and there was no significant difference between vitamin D3 and placebo groups.read more
Citations
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Journal ArticleDOI
Harrison's Principles of Internal Medicine
TL;DR: The 11th edition of Harrison's Principles of Internal Medicine welcomes Anthony Fauci to its editorial staff, in addition to more than 85 new contributors.
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Vitamin D deficiency.
TL;DR: It is suggested that if assessment of overdoses were left to house doctors there would be an increase in admissions to psychiatric units, outpatients, and referrals to social services, but for house doctors to assess overdoses would provide no economy for the psychiatric or social services.
Journal ArticleDOI
Vitamin D and inflammatory diseases
Kai Yin,Devendra K. Agrawal +1 more
TL;DR: The potential mechanisms of vitamin D in regulating immune/inflammatory responses in inflammatory diseases are discussed and a pleiotropic role in the pathogenesis of the diseases is considered.
Journal ArticleDOI
Effect of Vitamin D Supplementation on Pain: A Systematic Review and Meta-analysis
TL;DR: A significantly greater mean decrease in pain score was observed with vitamin D supplements compared with placebo in people with chronic pain, suggesting that vitamin D supplementation could have a role in the management of chronic pain.
Journal ArticleDOI
Guideline summary review: an evidence-based clinical guideline for the diagnosis and treatment of low back pain
D. Scott Kreiner,Paul G. Matz,Christopher M. Bono,Charles H. Cho,John E. Easa,Gary Ghiselli,Zoher Ghogawala,Zoher Ghogawala,Charles A. Reitman,Daniel K. Resnick,William C. Watters,Thiru M. Annaswamy,Jamie L. Baisden,Walter S. Bartynski,Shay Bess,Randall P. Brewer,R. Carter Cassidy,David S. Cheng,Sean Christie,Norman B. Chutkan,Bernard Allan Cohen,Simon Dagenais,Dennis E. Enix,Paul Dougherty,S. Raymond Golish,Padma Gulur,Steven W. Hwang,Cumhur Kilincer,Jeffrey A. King,Adam C. Lipson,Anthony J. Lisi,Richard J. Meagher,John E. O'Toole,Paul Park,Murat Pekmezci,Daniel R. Perry,Ravi Prasad,David A. Provenzano,Kris E. Radcliff,Gazanfar Rahmathulla,Tom E. Reinsel,Robert L. Rich,Daniel S. Robbins,Karie A. Rosolowski,Jonathan N. Sembrano,Anil K. Sharma,Alison A. Stout,Christopher K. Taleghani,Ryan A. Tauzell,Terry Trammell,Yakov Vorobeychik,Amy M. Yahiro +51 more
TL;DR: The evidence-based clinical guideline has been created using techniques of evidence- based medicine and best available evidence to aid practitioners in the diagnosis and treatment of adult patients with nonspecific low back pain.
References
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Journal ArticleDOI
Vitamin D Deficiency
TL;DR: The role of vitamin D in skeletal and nonskeletal health is considered and strategies for the prevention and treatment ofitamin D deficiency are suggested.
Journal ArticleDOI
Harrison's Principles of Internal Medicine
TL;DR: The 11th edition of Harrison's Principles of Internal Medicine welcomes Anthony Fauci to its editorial staff, in addition to more than 85 new contributors.
Journal ArticleDOI
Vitamin D deficiency.
TL;DR: It is suggested that if assessment of overdoses were left to house doctors there would be an increase in admissions to psychiatric units, outpatients, and referrals to social services, but for house doctors to assess overdoses would provide no economy for the psychiatric or social services.
Journal ArticleDOI
The prevalence of low back pain: A systematic review of the literature from 1966 to 1998
TL;DR: A systematic literature review of population prevalence studies of low back pain between 1966 and 1998 was conducted to investigate data homogeneity and appropriateness for pooling, and a model using uniform best-practice methods is proposed.
Journal ArticleDOI
The urgent need to recommend an intake of vitamin D that is effective
Reinhold Vieth,Heike A. Bischoff-Ferrari,Heike A. Bischoff-Ferrari,Barbara J. Boucher,Bess Dawson-Hughes,Cedric F. Garland,Robert P. Heaney,Michael F. Holick,Bruce W. Hollis,Christel Lamberg-Allardt,John J. McGrath,John J. McGrath,Anthony W. Norman,Robert Scragg,Susan J. Whiting,Walter C. Willett,Armin Zittermann +16 more
TL;DR: There is now strong evidence that increasing vitamin D intake will lower risk of falling and lower fracture risk in older men and women and regulatory agencies in the United States and abroad should review the evidence and reassess their dietary recommendations.