The Effects of Cannabinoids on Sleep
Bhanu Prakash Kolla,Lisa Hayes,Chaun Cox,Lindy Eatwell,Mark E. Deyo-Svendsen,Meghna P. Mansukhani +5 more
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TLDR
It is shown that cannabis products have minimal to no effects on sleep disorders and may have deleterious effects in some individuals and further research examining the differential impact of the various types of cannabinoids that are currently available on each of these sleep disorders is required.Abstract:
The use of cannabis products to help with sleep and various other medical conditions by the public has increased significantly in recent years. Withdrawal from cannabinoids can lead to sleep disturbance. Here, we describe a patient who developed significant insomnia leading to worsening anxiety, mood, and suicidal ideation in the setting of medical cannabis withdrawal, prompting presentation to the Emergency Department and inpatient admission. There is a limited evidence base for the use of cannabis products for sleep. We provide a comprehensive review evaluating the literature on the use of cannabis products on sleep, including an overview of cannabis and related psychoactive compounds, the current state of the law as it pertains to the prescribing and use of these substances, and potential side effects and drug interactions. We specifically discuss the impact of cannabis products on normal sleep and circadian sleep-wake rhythms, insomnia, excessive daytime sleepiness, sleep apnea, parasomnias, and restless legs syndrome. We also describe the effects of cannabis withdrawal on sleep and how this increases relapse to cannabis use. Most of the studies are observational but the few published randomized controlled trials are reviewed. Our comprehensive review of the effects of cannabis products on normal sleep and sleep disorders, relevant to primary care providers and other clinicians evaluating and treating patients who use these types of products, shows that cannabis products have minimal to no effects on sleep disorders and may have deleterious effects in some individuals. Further research examining the differential impact of the various types of cannabinoids that are currently available on each of these sleep disorders is required.read more
Citations
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Updates in the use of cannabis for insomnia
David C. Earl,Marco Proano +1 more
TL;DR: Clinicians should be aware of the potential effects of cannabis on the metabolism of other medications as well as the fact that cannabis use has been reported in a significant number of women in the periods before, during, and after pregnancy.
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The Effects of Long-Term Self-Dosing of Cannabidiol on Drowsiness, Testosterone Levels, and Liver Function
TL;DR: In this paper , the authors investigated the prevalences of male total testosterone (TT), elevations in liver tests (LTs), and daytime drowsiness (DD) in self-administering CBD and determined the effect self-dosing of CBD has on the severity of DD.
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The Perceived Effect of Cannabis Use on Penile Growth in Humans
TL;DR: For instance, this article found that men who reported using cannabis regularly had a statistically significant increase in perceived average penile length compared to those who did not use cannabis (p < 0.05).
Journal ArticleDOI
Updates in the use of cannabis for insomnia
TL;DR: In this paper , a review aims to summarize recent updates in the area of cannabis use for insomnia, focusing on the specific effects of cannabinoids on sleep varies with cannabinoid type and concentration, while other evidence is either lacking or in some cases contradictory.
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Association of dual electronic cigarettes and marijuana use with sleep duration among adults from the United States, NHANES 2015–2018
TL;DR: In this paper , the authors investigated the association between the dual use of e-cigarettes and marijuana with sleep duration among adults in the United States, using data from 6,573 participants aged 18-64 years from 2015 to 2018.
References
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Adverse Health Effects of Marijuana Use
TL;DR: As marijuana use becomes legal in some states, the dominant public opinion is that marijuana is a harmless source of mood alteration, but enough information is available to cause concern.
Journal ArticleDOI
Cannabinoids for Medical Use: A Systematic Review and Meta-analysis.
Penny Whiting,Penny Whiting,Robert Wolff,Sohan Deshpande,Marcello Di Nisio,Steven Duffy,Adrian V. Hernandez,Adrian V. Hernandez,J. Christiaan Keurentjes,Shona H. Lang,Kate Misso,Steve Ryder,Simone Schmidlkofer,Marie Westwood,Jos Kleijnen +14 more
TL;DR: There was moderate- quality evidence to support the use of cannabinoids for the treatment of chronic pain and spasticity and low-quality evidence suggesting that cannabinoids were associated with improvements in nausea and vomiting due to chemotherapy, weight gain in HIV infection, sleep disorders, and Tourette syndrome.
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Adverse health effects of non-medical cannabis use
Wayne Hall,Louisa Degenhardt +1 more
TL;DR: The most probable adverse effects include a dependence syndrome, increased risk of motor vehicle crashes, impaired respiratory function, cardiovascular disease, and adverse effects of regular use on adolescent psychosocial development and mental health.
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Acute cannabis consumption and motor vehicle collision risk: systematic review of observational studies and meta-analysis
TL;DR: Acute cannabis consumption is associated with an increased risk of a motor vehicle crash, especially for fatal collisions, and could be used as the basis for campaigns against drug impaired driving, developing regional or national policies to control acute drug use while driving, and raising public awareness.
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Proof of concept trial of dronabinol in obstructive sleep apnea
TL;DR: Dronabinol treatment is safe and well-tolerated in OSA patients at doses of 2.5–10 mg daily and significantly reduces AHI in the short-term and should be confirmed in a larger study in order to identify sub-populations with OSA that may benefit from cannabimimetic pharmacologic therapy.