The effects of different fractions of Coriandrum sativum on pentylenetetrazole-induced seizures and brain tissues oxidative damage in rats.
Akbar Anaeigoudari,Mahmoud Hosseini,Reza Karami,Farzaneh Vafaee,Toktam Mohammadpour,Ahmad Ghorbani,Hamid Reza Sadeghnia +6 more
TLDR
It is shown that different fractions of C. sativum possess antioxidant activity in the brain and WF and EAF of this plant have anticonvulsant effects.Abstract:
Objective: In the present work, the effects of different fractions of Coriandrum sativum (C. sativum), on pentylenetetrazole (PTZ)-induced seizures and brain tissues oxidative damage were investigated in rats. Materials and Methods: The rats were divided into the following groups: (1) vehicle, (2) PTZ (90 mg/kg), (3) water fraction (WF) of C. sativum (25 and 100 mg/kg), (4) n-butanol fraction (NBF) of C. sativum (25 and 100 mg/kg), and (5) ethyl acetate fraction (EAF) of C. sativum (25 and 100 mg/kg). Results: The first generalized tonic-clonic seizures (GTCS) latency in groups treated with 100 mg /kg of WF or EAF was significantly higher than that of PTZ group (p< 0.01). In contrast to WF, the EAF and NBF were not effective in increasing the first minimal clonic seizure (MCS) latency. Malondialdehyde (MDA) levels in both cortical and hippocampal tissues of PTZ group were significantly higher than those of control animals (p< 0.001). Pretreatment with WF, NBF, or EAF resulted in a significant reduction in the MDA levels of hippocampi (pConclusion: The present study showed that different fractions of C. sativum possess antioxidant activity in the brain and WF and EAF of this plant have anticonvulsant effects.read more
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Coriander (Coriandrum sativum): A promising functional food toward the well-being
TL;DR: This review shed light on comprehensive aspects regarding the therapeutic values of the C. sativum, which indicate its significance of being a promising functional food for promoting the well-being in the era of aging and lifestyle-related diseases.
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Liver Fatty Acid Binding Protein Deficiency Provokes Oxidative Stress, Inflammation, and Apoptosis-Mediated Hepatotoxicity Induced by Pyrazinamide in Zebrafish Larvae.
Yun Zhang,Kechun Liu,Hozeifa M. Hassan,Hozeifa M. Hassan,Hongli Guo,Pingping Ding,Liwen Han,Qiuxia He,Chen Weiyun,Chung-Der Hsiao,Luyong Zhang,Zhenzhou Jiang +11 more
TL;DR: The findings suggest that L-FABP-mediated PPAR-α downregulation appears to be a hepatotoxic response resulting from zebrafish larva liver cell apoptosis, and L-fABP can be used as a biomarker for the early detection of PZA-induced liver damage in zebra fish larvae.
Journal ArticleDOI
Anticonvulsant Activity of Viola tricolor against Seizures Induced by Pentylenetetrazol and Maximal Electroshock in Mice.
Vafa Baradaran Rahimi,Vahid Reza Askari,Mahmoud Hosseini,Bahareh Sadat Yousefsani,Hamid Reza Sadeghnia +4 more
TL;DR: The present study showed that V. tricolor and its ethyl acetate and n-butanol fractions possessed anticonvulsant effects as confirmed by the prolongation of latency to the first GTCs induced by PTZ and decrement in the incidence of HLTE induced by MES.
Journal ArticleDOI
Ameliorative potential of Colebrookea oppositifolia methanolic root extract against experimental models of epilepsy: Possible role of GABA mediated mechanism
Gollapalle Lakshminarayanashastry Viswanatha,Marikunte V Venkataranganna,Nunna Bheema Lingeswara Prasad +2 more
TL;DR: In this paper, the anticonvulsant activity of the roots of Colebrookea oppositifolia using various experimental models of epilepsy in mice was evaluated, and the results indicated that MeCO possess significant ant-convulsant action and the outcomes further confirmed the involvement of GABAergic mechanisms behind the ant-consistent activity of MeCO.
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TL;DR: PTZ might be suitable for predicting efficacy against myoclonic petit mal seizures in humans, but certainly not to predict efficacy against absence seizures, and various factors delineated in this study should be rigidly controlled in experimental situations involving assay of anticonvulsant agents.