The fate of melatonin in animals.
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TLDR
The synthesis of melatonin labeled in three different positions with Cl4 or H3, the physiological disposition of administered hormone, and its metabolism in uivo and in animal studies are described.About:
This article is published in Journal of Biological Chemistry.The article was published on 1961-11-01 and is currently open access. It has received 340 citations till now. The article focuses on the topics: 6-Hydroxymelatonin & Melatonin.read more
Citations
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Pineal Melatonin: Cell Biology of Its Synthesis and of Its Physiological Interactions*
TL;DR: The pineal gland can be rapidly removed from rodents with minimal damage to adjacent neural structures using a specially designed trephine, and since the mid 1960s, research on the gland has become a very active area of investigation.
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Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters
TL;DR: The aim of this review is to gather together early and recent data on the effects of the nonadrenergic transmitters on modulation of melatonin synthesis, which reveals the variety of inputs that can be integrated by the pineal gland; what elements are crucial to deliver the very precise timing information to the organism.
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The release and fate of vaso‐active hormones in the circulation
TL;DR: Some of Gaddum's first publications were on the development of specific and sensitive methods for biological assay, and he maintained a deep interest in this subject for the rest of his life.
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Gastrointestinal melatonin: localization, function, and clinical relevance.
TL;DR: Because of its unique properties, melatonin could be considered for prevention or treatment of colorectal cancer, ulcerative colitis, gastric ulcers, irritable bowel syndrome, and childhood colic.
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Cellular Mechanisms of Melatonin Action
TL;DR: Molecular mechanisms of the melatonin effects are not clear but may involve at least two parallel transduction pathways, one inhibiting adenylyl cyclase and the other regulating phospholipide metabolism and [Ca2+]i.
References
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Purification and properties of hydroxyindole-O-methyl transferase.
Julius Axelrod,Herbert Weissbach +1 more
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Biosynthesis of melatonin: enzymic conversion of serotonin to N-acetylserotonin.
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The distribution and metabolism of lysergic acid diethylamide.
TL;DR: This first of several articles on the narcotic drug, Axelrod detailed the subcellular processes involved in the transformation of LSD, determined the order of concentrations of the drug in various tissues, and determined that it was almost completely metabolized by the body.
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Melatonin in Peripheral Nerve
TL;DR: With improvement in extraction techniques, the presence of a lightening agent that is most likely melatonin in peripheral nerves of man, monkey and cow is identified.
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Purification and properties of hydroxyindole-O-methyl transferase.
Julius Axelrod,Herbert Weissbach +1 more