Journal ArticleDOI
The frequency of the mitochondrial aldehyde dehydrogenase I2 (atypical) allele in Caucasian, Oriental and African black populations determined by the restriction profile of PCR-amplified DNA.
F Dandré,A. Cassaigne,A. Iron +2 more
TLDR
A procedure for ALDH I2 detection consisting in a differentiation between the 'atypical' allele and the 'wild' allele has been improved through PCR and subsequent MboII digestion, which permits a rapid and non-radioactive detection of atypical AL DH I2 on a PCR product without the use of allele specific oligonucleotides.About:
This article is published in Molecular and Cellular Probes.The article was published on 1995-06-01. It has received 43 citations till now. The article focuses on the topics: Allele frequency & Aldehyde dehydrogenase.read more
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Journal ArticleDOI
Targeting aldehyde dehydrogenase 2: new therapeutic opportunities
TL;DR: New research suggests that ALDH2 dysfunction may contribute to a variety of human diseases including cardiovascular diseases, diabetes, neurodegenerative diseases, stroke, and cancer, and epidemiological studies suggest a correlation between this inactivating mutation and increased propensity for common human pathologies.
Journal ArticleDOI
Interaction between the Functional Polymorphisms of the Alcohol-Metabolism Genes in Protection against Alcoholism
Chiao Chicy Chen,Ru Band Lu,Yi Chyan Chen,Ming-Fang Wang,Yue-Cune Chang,Ting-Kai Li,Shih Jiun Yin +6 more
TL;DR: It is suggested that protection afforded by the ADH2*2 allele may be independent of that afforded by ALDH2* 2, and that individuals carrying one or two copies of ADH 2 and a single copy of ALDH 2*2 had the lowest risk for alcoholism, as compared with the ADh2*1/*1 and ALDH1*1 genotype.
Journal ArticleDOI
Possible interaction of alcohol dehydrogenase and aldehyde dehydrogenase genes with the dopamine D2 receptor gene in anxiety-depressive alcohol dependence.
San Yuan Huang,Wei-Wen Lin,Huei Chen Ko,Jia-Fu Lee,Tso-Jen Wang,Yuan-Hwa Chou,Shih-Jiun Yin,Ru Band Lu +7 more
TL;DR: ANX/DEP ALC is a specific subtype of alcohol dependence and the DRD2 gene was not found to be associated with pure alcohol dependence or ANx/DEP, but was found to been associated with ANX/DEV ALC.
Journal ArticleDOI
Alcohol metabolism and cardiovascular response in an alcoholic patient homozygous for the ALDH2*2 variant gene allele.
Yi Chyan Chen,Ru Band Lu,Giia Sheun Peng,Ming-Fang Wang,Hsu Kun Wang,Huei Chen Ko,Yue-Cune Chang,Jang Jih Lu,Ting-Kai Li,Shih Jiun Yin +9 more
TL;DR: Logistic regression analysis of the combinatorial genotypes of ADH2 and ALDH2 in 420 alcohol-dependent and 689 nonalcohol-dependent subjects indicated that risk for alcoholism was 100-fold lower for theADH2*2/*2-ALDH2* 2/*2 individuals than the ADH*1/*1-AL DH2*1*1 individuals.
Journal ArticleDOI
Allelic variation at alcohol metabolism genes (ADH1B, ADH1C, ALDH2) and alcohol dependence in an American Indian population
Connie J. Mulligan,Robert W. Robin,Michael V. Osier,Nyamkhishig Sambuughin,Lev G. Goldfarb,Rick A. Kittles,Diane Hesselbrock,David Goldman,Jeffrey C. Long +8 more
TL;DR: Assays of DNA extracts from participants belonging to a Southwest American Indian tribe with a high prevalence of alcoholism strengthen the support for ADH as a candidate locus for alcohol dependence and suggest further productive study.