Open AccessJournal Article
The human erg gene maps to chromosome 21, band q22: relationship to the 8; 21 translocation of acute myelogenous leukemia.
Veena Rao,William S. Modi,H. D. Drabkin,D. F. Patterson,Stephen J. O'Brien,Takis S. Papas,E. S. Reddy +6 more
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TLDR
In this paper, the erg gene was found to translocate from chromosome 21 to 8 in the t(8, 21) (q22; q22), a nonrandom translocation found in patients with acute myelogenous leukemia of the subgroup M2 (AML-M2).Abstract:
There is accumulating evidence to support that genes on chromosome 21 play an important role in the development of pathologies associated with leukemia, Down's syndrome, and Alzheimer's disease. We have previously described erg, a human gene related to the ets oncogene. In this study, we have regionally assigned the erg gene to chromosome 21q22.3 by using somatic cell hybrids and in situ hybridization analysis. In light of this chromosome assignment, the relationship of erg to the 21q translocation breakpoint characteristic of acute myelogenous leukemia (AML) was considered. By using a DNA probe that is specific for the erg gene, a panel of rodent-human cell hybrids was analyzed by the Southern technique to study specific chromosome translocations occurring in acute myeloblastic leukemia. The erg gene was found to translocate from chromosome 21 to 8 in the t(8; 21) (q22; q22), a non-random translocation found in patients with acute myelogenous leukemia of the subgroup M2 (AML-M2). The localization of the erg gene to chromosome 21q22 raises the possibility that this gene may be involved in the pathogenesis of AML-M2.read more
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elk, tissue-specific ets-related genes on chromosomes X and 14 near translocation breakpoints
TL;DR: Two new members (elk-1 and elk-2) of the ets oncogene superfamily have now been identified and the possibility that rearrangements of elk loci may be involved in pathogenesis of certain tumors is suggested.
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Down syndrome congenital heart disease: a narrowed region and a candidate gene.
Gillian M. Barlow,Xiao Ning Chen,Zheng Y. Shi,Gary E. Lyons,David M. Kurnit,Livija Celle,Nancy B. Spinner,Elaine H. Zackai,Mark J. Pettenati,Alexander J. Van Riper,Michael J. Vekemans,Corey H. Mjaatvedt,Julie R. Korenberg +12 more
TL;DR: Human molecular and cardiac data suggest that the presence of three copies of gene(s) from the region is sufficient for the production of subsets of DS-CHD, and DSCAM (Down syndrome cell adhesion molecule) is proposed as a candidate gene.
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10 years of Genomics, chromosome 21, and Down syndrome
TL;DR: The future goals of genomic analysis of HC21 will be the determination of its complete nucleotide sequence and the identification and functional analysis of all of its genes, to provide a molecular explanation of the pathophysiology of Down syndrome.
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ERP, a new member of the ets transcription factor/oncoprotein family: cloning, characterization, and differential expression during B-lymphocyte development.
TL;DR: Cloned the gene for a new ets-related transcription factor, ERP (ets-related protein), from the murine pre-B cell line BASC 6C2 and from mouse lung tissue, and data suggest that ERP might play a role in B-cell development and in IgH gene regulation.
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ERG gene is translocated in an Ewing's sarcoma cell line
TL;DR: A general mechanism of generating putative oncogenic fusion genes by placing an ETS DNA binding domain in direct proximity to the carboxy terminus domain (CTD) related region of the EWS gene is confirmed.