Journal ArticleDOI
The hypertrophic scar. Glycoprotein and collagen components of burn scars.
M. R. Shetlar,M. Dobrkovsky,Hugo A. Linares,Rebecca Villarante,C. L. Shetlar,Duane L. Larson +5 more
TLDR
It is concluded that hypertrophic scars contain more glycoprotein and mucopolysaccharide and are more active metabolically.Abstract:
SummaryA study of the hexose hexosamine, sialic acid, uronic acid, glycogen, and collagen fractions has been made on hypertrophic scars, nonhypertrophic scars, and normal skin. Hexose, hexosamine, sialic acid, uronic acid, and glycogen levels were significantly and consistently elevated in hypertrophic scars. These same components were slightly, but significantly, higher in the nonhypertrophic scars. Salt-soluble collagen of hypertrophic scars was significantly elevated, citrate-soluble and insoluble collagen fractions were not different in the three groups. From these data it is concluded that hypertrophic scars contain more glycoprotein and mucopolysaccharide and are more active metabolically.read more
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On the nature of hypertrophic scars and keloids : A review
TL;DR: On the Nature of Hypertrophic Scars and Keloids: A Review Frank Niessen;Paul Spauwen;Joost Schalkwijk;Moshe Kon; Plastic and Reconstructive Surgery.
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Keloids: A review
TL;DR: Keloid treatments have been attempted, but variable success has followed either single use or combinations of intralesional corticosteroid injection, surgery, pressure devices, radiation, cryosurgery, and systemic chemotherapy.
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Atypical keloids after dermabrasion of patients taking isotretinoin.
TL;DR: Six patients underwent dermabrasion while on or having recently completed isotretinoin (Accutane) therapy, and all patients developed keloid in atypical locations; the keloids eventually responded to topical or intralesional steroid therapy.
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Alteration of hypertrophic scars induced by mechanical pressure.
TL;DR: It is suggested that the application of pressure increases an already present condition of hypoxia, which results in degeneration of many fibroblasts, and the ratio of collagen synthesis to degradation would be altered in favor of the latter, resulting in resolution of the scar.
Journal ArticleDOI
Keratinocyte-derived growth factors play a role in the formation of hypertrophic scars.
TL;DR: Observations support the possibility that the epidermis is involved in preventing the formation of hypertrophic scars, after biopsies taken from breast reduction scars at 3 and 12 months following surgery.