Journal ArticleDOI
The impact of overactive bladder, incontinence and other lower urinary tract symptoms on quality of life, work productivity, sexuality and emotional well-being in men and women: results from the EPIC study.
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TLDR
To examine the effect overactive bladder (OAB) and other lower urinary tract symptoms (LUTS) on health‐related quality of life (HRQoL) in a population sample, as OAB often occurs in conjunction with many other LUTS.Abstract:
OBJECTIVES
To examine the effect overactive bladder (OAB) and other lower urinary tract symptoms (LUTS) on health-related quality of life (HRQoL) in a population sample, as OAB often occurs in conjunction with many other LUTS.
SUBJECTS AND METHODS
A nested case-control analysis was performed on men and women with (cases) and without (controls) OAB, from the EPIC study. OAB was assessed using 2002 International Continence Society definitions. Based on their responses to questions about LUTS, cases were classified into five groups; continent OAB, OAB with incontinence, OAB + postmicturition, OAB + voiding, and OAB + postmicturition + voiding. Both cases and controls were asked questions about symptom bother (OAB-q), generic QoL (EQ-5D), work productivity (Work Productivity and Activity Impairment, WPAI), depressive symptoms (Center for Epidemiologic Studies Depression Scale), sexual satisfaction, and erectile dysfunction (men only) using the Massachusetts Male Aging Study. Cases answered additional condition-specific questions HRQoL (OAB-q short form), Patient Perception of Bladder Condition and work productivity related to a specific health problem (WPAI-SHP). General linear models were used to evaluate group differences.
RESULTS
Of the EPIC participants, 1434 identified OAB cases were matched by age, gender and country, with 1434 participants designated as controls. Cases and controls were primarily Caucasian (96.2% and 96.7%, respectively), and most (65%) were female; the mean age was 53.8 and 53.7 years, respectively. Comorbid conditions differed significantly by case/control status, with cases reporting significantly greater rates of chronic constipation, asthma, diabetes, high blood pressure, bladder or prostate cancer, neurological conditions and depression. There were significant differences between the cases and controls in all reported LUTS. The OAB + postmicturition + voiding group reported significantly greater symptom bother, worse HRQoL, higher rates of depression and decreased enjoyment of sexual activity, than the other subgroups.
CONCLUSION
OAB has a substantial, multidimensional impact on patients; OAB with additional LUTS has a greater impact. The diagnosis and treatment of OAB should be considered in conjunction with other LUTS, to maximize treatment options and optimize patient outcomes.read more
Citations
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Journal ArticleDOI
Worldwide prevalence estimates of lower urinary tract symptoms, overactive bladder, urinary incontinence and bladder outlet obstruction
TL;DR: Study Type – Symptom prevalence (prospective cohort) and Cause of Death – Causes of Death and Mortality (Prospective cohort).
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Efficacy and safety of onabotulinumtoxinA for idiopathic overactive bladder: a double-blind, placebo controlled, randomized, dose ranging trial.
Roger R. Dmochowski,Christopher R. Chapple,Victor W. Nitti,Michael B. Chancellor,Karel Everaert,Catherine Thompson,Grace Daniell,Jihao Zhou,Jihao Zhou,Cornelia Haag-Molkenteller +9 more
TL;DR: A dose of 100 U may be the dose that appropriately balances the symptom benefits with the post-void residual urine volume related safety profile in the management of idiopathic overactive bladder and urinary urgency incontinence.
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OnabotulinumtoxinA 100 U Significantly Improves All Idiopathic Overactive Bladder Symptoms and Quality of Life in Patients with Overactive Bladder and Urinary Incontinence: A Randomised, Double-Blind, Placebo-Controlled Trial
Christopher R. Chapple,Karl-Dietrich Sievert,Scott MacDiarmid,Vik Khullar,Piotr Radziszewski,Christopher Nardo,Catherine Thompson,J. Zhou,Cornelia Haag-Molkenteller +8 more
TL;DR: OnabotulinumtoxinA 100 U was well tolerated and demonstrated significant and clinically relevant improvements in all OAB symptoms, patient-reported benefit, and HRQOL in patients inadequately managed by anticholinergics.
Journal ArticleDOI
OnabotulinumtoxinA for the Treatment of Patients with Overactive Bladder and Urinary Incontinence: Results of a Phase 3, Randomized, Placebo Controlled Trial
Victor W. Nitti,Roger R. Dmochowski,Sender Herschorn,Peter K. Sand,Catherine Thompson,Christopher Nardo,Xiaohong Yan,Cornelia Haag-Molkenteller +7 more
TL;DR: OnabotulinumtoxinA 100 U showed significant, clinically relevant improvement in all overactive bladder symptoms and health related quality of life in patients inadequately treated with anticholinergics and was well tolerated.
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Persistence and adherence in the treatment of overactive bladder syndrome with anticholinergic therapy: a systematic review of the literature.
C. Sexton,S. M. Notte,C. Maroulis,Roger R. Dmochowski,Linda Cardozo,Dhinagar Subramanian,Karin S. Coyne +6 more
TL;DR: The low levels of persistence and adherence documented in this review reveal cause for concern about the balance between the efficacy and tolerability of anticholinergic agents and new agents and non‐pharmacologic alternatives with good efficacy and minimal side effects should be explored.
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