The impact of vitamin D deficiency on immune T cells in asthmatic children: a case-control study
Haifa Maalmi,Anissa Berraies,E. Tangour,Jamel Ammar,Hanadi Abid,Kamel Hamzaoui,Agnes Hamzaoui +6 more
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TLDR
The findings suggest that vitamin D is an important promoter of T cell regulation in vivo in young asthmatics, and even in a southern Mediterranean country, hypovitaminosis D is frequent in children with asthma.Abstract:
Background
Vitamin D exerts profound effects on both adaptive and innate immune functions involved in the development and course of autoimmune and inflammatory diseases. As the incidence of vitamin D insufficiency is surprisingly high in the general population, experimental studies have started to investigate whether vitamin D levels (measured as serum 25 hydroxy vitamin D-25[OH]D) are correlated with immune cells and clinical parameters.read more
Citations
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Vitamin D deficiency.
TL;DR: It is suggested that if assessment of overdoses were left to house doctors there would be an increase in admissions to psychiatric units, outpatients, and referrals to social services, but for house doctors to assess overdoses would provide no economy for the psychiatric or social services.
Journal ArticleDOI
Association of the adam33 gene with asthma and bronchial hyperresponsiveness
TL;DR: The identification and characterization of ADAM33, a putative asthma susceptibility gene identified by positional cloning in an outbred population, should provide insights into the pathogenesis and natural history of this common disease.
Journal ArticleDOI
Vitamin D supplementation in primary allergy prevention: Systematic review of randomized and non-randomized studies
Juan José Yepes-Nuñez,Juan José Yepes-Nuñez,Jan Brozek,Alessandro Fiocchi,Ruby Pawankar,Carlos A. Cuello-Garcia,Carlos A. Cuello-Garcia,Ying Zhang,Gian Paolo Morgano,Arnav Agarwal,Shreyas Gandhi,Luigi Terracciano,Holger J. Schünemann +12 more
TL;DR: To date, a systematic review of the evidence regarding the association between vitamin D and allergic diseases development has not yet been undertaken.
Journal ArticleDOI
Vitamin D deficiency induces Th2 skewing and eosinophilia in neonatal allergic airways disease
Jessica Vasiliou,Stephen Lui,Simone A. Walker,V. Chohan,Emmanuel Xystrakis,Andrew Bush,Catherine M. Hawrylowicz,Sejal Saglani,Claire M. Lloyd +8 more
TL;DR: The effect of early‐life vitamin D deficiency on the development of murine neonatal allergic airways disease (AAD) is investigated.
Journal ArticleDOI
Immunoregulatory mechanisms of vitamin D relevant to respiratory health and asthma.
TL;DR: The mechanisms by which vitamin D may protect against asthma are looked at, including increasing glucocorticoid responsiveness, skewing immune cells towards a regulatory phenotype, reducing the incidence of infections, airway remodeling, eosinophilia, and lowering the levels of IgE.
References
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Journal ArticleDOI
Vitamin D Deficiency
TL;DR: The role of vitamin D in skeletal and nonskeletal health is considered and strategies for the prevention and treatment ofitamin D deficiency are suggested.
Journal ArticleDOI
Vitamin D deficiency.
TL;DR: It is suggested that if assessment of overdoses were left to house doctors there would be an increase in admissions to psychiatric units, outpatients, and referrals to social services, but for house doctors to assess overdoses would provide no economy for the psychiatric or social services.
Journal ArticleDOI
Global strategy for asthma management and prevention: GINA executive summary.
Eric D. Bateman,Suzanne S. Hurd,Peter J. Barnes,Jean Bousquet,Jeffrey M. Drazen,JM FitzGerald,Peter G. Gibson,K. Ohta,Paul M. O'Byrne,Søren Pedersen,Emilio Pizzichini,Sean D. Sullivan,Sally E. Wenzel,Heather J. Zar +13 more
TL;DR: It is reasonable to expect that in most patients with asthma, control of the disease can and should be achieved and maintained, and the Global Initiative for Asthma recommends a change in approach to asthma management, with asthma control, rather than asthma severity, being the focus of treatment decisions.
Journal ArticleDOI
Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes
Heike A. Bischoff-Ferrari,Edward Giovannucci,Walter C. Willett,Thomas Dietrich,Bess Dawson-Hughes +4 more
TL;DR: Evidence from studies that evaluated thresholds for serum 25(OH)D concentrations in relation to bone mineral density, lower-extremity function, dental health, and risk of falls, fractures, and colorectal cancer suggests that an increase in the currently recommended intake of vitamin D is warranted.
Journal ArticleDOI
Vitamin effects on the immune system: vitamins A and D take centre stage
TL;DR: The current understanding of the essential roles of vitamins in modulating a broad range of immune processes, such as lymphocyte activation and proliferation, T-helper-cell differentiation, tissue-specific lymphocyte homing, and the production of specific antibody isotypes and regulation of the immune response are presented.