Journal ArticleDOI
The induction of antigenic changes in a teratocarcinoma stem cell line (f9) by retinoic acid.
Davor Solter,Davor Solter,Lynne Hamburger Shevinsky,Lynne Hamburger Shevinsky,Barbara B. Knowles,Barbara B. Knowles,Sidney Strickland,Sidney Strickland +7 more
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TLDR
Evidence indicates that the phenotypic changes that accompany retinoic acid treatment of embryonal carcinoma cells are irreversible and a consequence of the differentiation of the cells into endoderm.About:
This article is published in Developmental Biology.The article was published on 1979-06-01. It has received 159 citations till now. The article focuses on the topics: P19 cell & Cellular differentiation.read more
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Hormonal induction of differentiation in teratocarcinoma stem cells: generation of parietal endoderm by retinoic acid and dibutyryl cAMP.
TL;DR: The cell type generated by retinoic acid and dibutyryl cAMP treatment is therefore indistinguishable from definitive parietal endoderm, and analysis of the final phenotype indicates that it is not dependent upon the continued presence of either compound, and that cAMP agents are active only on cells that have been treated with retinoi acid.
Journal ArticleDOI
Preimplantation Human Embryos and Embryonic Stem Cells Show Comparable Expression of Stage‐Specific Embryonic Antigens
J. K. Henderson,Jonathan S. Draper,H. S. Baillie,S. Fishel,James A. Thomson,Harry Moore,Peter W. Andrews +6 more
TL;DR: It is shown that human ES cells are characterized by the expression of the cell‐surface antigens, SSEA3, S SEA4, TRA‐1‐60, and TRA‐ 1‐81, and by the lack of SSEA1, and that inner cell mass cells of the human blastocyst express a similar antigen profile, in contrast to the corresponding Cells of the mouse embryo.
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Cell interactions modulate embryonal carcinoma cell differentiation into parietal or visceral endoderm
TL;DR: If F9 EC cultures are treated with retinoic acid when they are in the form of small aggregates, they differentiate on the outer surface cells which morphologically resemble visceral rather than parietal endoderm, and it is believed that F9EC cells may be even more useful than previously supposed for biochemical studies on factors controlling gene expression during mammalian embryogenesis.
Journal ArticleDOI
Epidermal growth factor receptors.
TL;DR: There is ample evidence that EGF binds to the receptor; that ligand-receptor complexes cluster or aggregate; and then are internalized and degraded, but evidence for a direct connection between internalization and the subsequent mitogenic response is lacking, and an alternative model is suggested.
Journal ArticleDOI
Immunohistochemical localization of the early embryonic antigen (SSEA-1) in postimplantation mouse embryos and fetal and adult tissues.
Niles Fox,Niles Fox,Ivan Damjanov,Ivan Damjanov,Antonio Martinez-Hernandez,Antonio Martinez-Hernandez,Barbara B. Knowles,Davor Solter +7 more
TL;DR: In adult mice, the epithelium of the oviduct, the endometrium, and the epididymis are the cells most reactive with the monoclonal antibody to SSEA-1; although some areas of the brain and kidney tubules are weakly positive.
References
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Journal ArticleDOI
Tissue changes following deprivation of fat-soluble a vitamin
S. Burt Wolbach,Percy R. Howe +1 more
TL;DR: The specific tissue changes which follow the deprivation of fat-soluble vitamin A in albino white rats and in the human concerns epithelial tissues are described and it is concluded that the deficiency results in loss of specific (chemical) functions of the epitheliums concerned, while the power of growth becomes augmented.
Journal ArticleDOI
The induction of differentiation in teratocarcinoma stem cells by retinoic acid
Sidney Strickland,Vijak Mahdavi +1 more
TL;DR: Using one embryonal carcinoma cell line, F9, it is found that retinoic acid at concentrations as low as 10(-9) M induces multiple phenotypic changes in the cultures in vitro, which are consistent with the proposition that retinosic acid induces differentiation of embryonal cancer cells into endoderm.
Journal ArticleDOI
Monoclonal antibody defining a stage-specific mouse embryonic antigen (SSEA-1).
Davor Solter,Barbara B. Knowles +1 more
TL;DR: A monoclonal antibody derived by fusion of mouse myeloma cells with spleen cells from a mouse immunized with F9 teratocarcinoma cells is described, which defines an embryonic stage-specific antigen.
Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids).
TL;DR: An approach to chemoprevention of common forms of epithelial cancer, during the period of preneoplasia, is described and the potential future usefulness of this approach to cancer prevention in man will depend on further synthetic modification of the retinoid molecule.
Journal ArticleDOI
Alkaline phosphatase activity in mouse teratoma.
TL;DR: The embryonal carcinoma enzyme resembles the enzymes from kidney and placenta in kinetics of thermal inactivation and sensitivity to the inhibitor L-phenylalanine, but is distinguishable from the alkaline phosphatases of liver and intestine.
Related Papers (5)
The induction of differentiation in teratocarcinoma stem cells by retinoic acid
Sidney Strickland,Vijak Mahdavi +1 more
Monoclonal antibody defining a stage-specific mouse embryonic antigen (SSEA-1).
Davor Solter,Barbara B. Knowles +1 more