Anthony R. Rees

TL;DR: Using peptide mapping to determine 'active' antigen recognition residues, molecular modeling, and a molecular dynamics trajectory analysis, a peptide mimic of an anti-CD4 antibody is developed, containing antigen contact residues from multiple CDRs.

TL;DR: In vitro study of the cellular uptake of peptides, originally deriving from protegrin (the SynB peptide vectors), that have also been shown to enhance the transport of drugs across the blood-brain barrier suggest that SynB and pAntp-(43–58) peptides penetrate into cells by an adsorptive-mediated endocytosis process rather than temperature-independent translocation.

TL;DR: Resurfaced N901 and anti-B4 antibodies had apparent affinities for their cell surface ligands that were identical to those of their respective parent murine antibodies, suggesting that, despite the differences in the surfaces of mouse and human Fv regions, it is possible to substitute one for the other while retaining full antigen binding affinity.

TL;DR: The isolation of a homeo box-containing gene that belongs to a new family of which there are at least three related genes in the mouse genome, and the homeobox of this new gene shows remarkable similarity to the Drosophila MshHomeo box that is designated as the prototype for this family.

TL;DR: There is ample evidence that EGF binds to the receptor; that ligand-receptor complexes cluster or aggregate; and then are internalized and degraded, but evidence for a direct connection between internalization and the subsequent mitogenic response is lacking, and an alternative model is suggested.