Journal ArticleDOI
The inhibition of renal ATPase by cisplatin and some bio-transformation products
P.T. Daley-Yates,D.C.H. McBrien +1 more
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TLDR
It is concluded that cisplatin reacts directly with ATPase rather than that a hydrolysis product is responsible for the inhibition, and that di-substituted methionine/cisplatin is less effective.About:
This article is published in Chemico-Biological Interactions.The article was published on 1982-07-01. It has received 78 citations till now. The article focuses on the topics: Cisplatin & ATPase.read more
Citations
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Why Does Cisplatin Reach Guanine-N7 with Competing S-Donor Ligands Available in the Cell?
Journal ArticleDOI
Comparative Adverse Effect Profiles of Platinum Drugs
TL;DR: Strong relationships between carboplatin renal clearance, glomerular filtration rate, area under the plasma concentration-time curve (AUC) of filterable platinum and severity of thrombocytopenia have prompted dose adjustment according to renal function.
Journal ArticleDOI
Characterization of the reactions of platinum antitumor agents with biologic and nonbiologic sulfur-containing nucleophiles
Peter C. Dedon,Richard F. Borch +1 more
TL;DR: The reactions of several platinum antitumor agents with sulfur-containing amino acids, peptides, proteins, and nonbiologic nucleophiles are characterized and DDTC and thiourea were shown to restore activity to platinum-inhibited enzymes.
Journal ArticleDOI
Cisplatin metabolites in plasma, a study of their pharmacokinetics and importance in the nephrotoxic and antitumour activity of cisplatin
TL;DR: Evidence is presented which suggests that amongst the principle metabolite species are an hydrolysis product and methionine substitution products of cisplatin, which are more nephrotoxic but less effective antitumour agents than the parent compound.
Journal Article
Effect of Diethyldithiocarbamate on cis-Diamminedichloroplatinum(II)-induced Cytotoxicity, DNA Cross-Linking, and γ-Glutamyl Transpeptidase Inhibition
TL;DR: Data indicate that DDTC has unique chemical specificity in its reactions with platinum complexes and that this specificity is ideal for application as a chemoprotective drug against cis-platinum toxicity.
References
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Journal ArticleDOI
A micro-biuret method for estimating proteins.
Ruth F. Itzhaki,D.M. Gill +1 more
TL;DR: Measurements on several dipeptides showed that proline peptide do not form ultraviolet-absorbing complexes with copper whereas prolyl peptides do form such complexes, which explains the finding that gelatin (which has a high proportion of proline and of hydroxyproline residues) is less reactive with copper than are the other proteins studied here.
Journal ArticleDOI
High dose cis-platinum diammine dichloride: amelioration of renal toxicity by mannitol diuresis.
Daniel M. Hayes,Esteban Cvitkovic,Robert B. Golbey,Ellen Scheiner,Lawrence Helson,Irwin H. Krakoff +5 more
TL;DR: A clinical trial was undertaken to improve the therapeutic index of cis‐plati‐num diammine dichloride with a concomitantly administered mannitol induced diuresis and CPDD administration, with Clinically significant responses in epidermoid carcinoma of the head and neck, adenocarcinomas of the ovary, and germ cell tumors of the testis.
Related Papers (5)
Characterization of the reactions of platinum antitumor agents with biologic and nonbiologic sulfur-containing nucleophiles
Peter C. Dedon,Richard F. Borch +1 more