Journal ArticleDOI
The Mathematics of Infectious Diseases
TLDR
Threshold theorems involving the basic reproduction number, the contact number, and the replacement number $R$ are reviewed for classic SIR epidemic and endemic models and results with new expressions for $R_{0}$ are obtained for MSEIR and SEIR endemic models with either continuous age or age groups.Abstract:
Many models for the spread of infectious diseases in populations have been analyzed mathematically and applied to specific diseases. Threshold theorems involving the basic reproduction number $R_{0}$, the contact number $\sigma$, and the replacement number $R$ are reviewed for the classic SIR epidemic and endemic models. Similar results with new expressions for $R_{0}$ are obtained for MSEIR and SEIR endemic models with either continuous age or age groups. Values of $R_{0}$ and $\sigma$ are estimated for various diseases including measles in Niger and pertussis in the United States. Previous models with age structure, heterogeneity, and spatial structure are surveyed.read more
Citations
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Journal ArticleDOI
The Structure and Function of Complex Networks
TL;DR: Developments in this field are reviewed, including such concepts as the small-world effect, degree distributions, clustering, network correlations, random graph models, models of network growth and preferential attachment, and dynamical processes taking place on networks.
Journal ArticleDOI
Complex networks: Structure and dynamics
TL;DR: The major concepts and results recently achieved in the study of the structure and dynamics of complex networks are reviewed, and the relevant applications of these ideas in many different disciplines are summarized, ranging from nonlinear science to biology, from statistical mechanics to medicine and engineering.
Journal ArticleDOI
Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission
TL;DR: A precise definition of the basic reproduction number, R0, is presented for a general compartmental disease transmission model based on a system of ordinary differential equations and it is shown that, if R0<1, then the disease free equilibrium is locally asymptotically stable; whereas if R 0>1,Then it is unstable.
Book
Modeling Infectious Diseases in Humans and Animals
TL;DR: Mathematical modeling of infectious dis-eases has progressed dramatically over the past 3 decades and continues to be a valuable tool at the nexus of mathematics, epidemiol-ogy, and infectious diseases research.
Journal ArticleDOI
Epidemic processes in complex networks
TL;DR: A coherent and comprehensive review of the vast research activity concerning epidemic processes is presented, detailing the successful theoretical approaches as well as making their limits and assumptions clear.
References
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Journal ArticleDOI
On the definition and the computation of the basic reproduction ratio R0 in models for infectious diseases in heterogeneous populations
TL;DR: It is shown that in certain special cases one can easily compute or estimate the expected number of secondary cases produced by a typical infected individual during its entire period of infectiousness in a completely susceptible population.