Journal ArticleDOI
The metabolism of styrene in the rat and the stimulatory effect of phenobarbital.
Hatsue Ohtsuji,Masayuki Ikeda +1 more
TLDR
The results together with those from previous studies support the following pathway of styrene metabolism in the rat: the metabolism proceeds through the oxidative conversion to a more toxic compound.About:
This article is published in Toxicology and Applied Pharmacology.The article was published on 1971-02-01. It has received 105 citations till now. The article focuses on the topics: Styrene oxide & Styrene.read more
Citations
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A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans.
TL;DR: Results show that physiologically based pharmacokinetic models provide a rational basis with which to explain the relationship between blood concentration and air concentration of an inhaled chemical, and to extrapolate this relationship from experimental animals to humans.
Journal ArticleDOI
Review of the toxicology of styrene.
TL;DR: Needed areas of future research on styrene include studies on the molecular dosimetry of styrene in terms of both hemoglobin and DNA adducts, which should improve the ability to assess the relationship between exposure to styrene and surrogate measures of "effective dose", thereby improving the able to estimate the effects of low-level human exposures.
Journal ArticleDOI
Metabolism and toxicity of styrene.
TL;DR: Reports of organ toxicity upon chronic exposure to styrene are rare; however, since the chief intermediate in styrene metabolism is an epoxide, hepatotoxicity due to covalent binding at the site of formation appears to be a possibility.
Journal ArticleDOI
Phenobarbital-induced protection against toxicity of toluene and benzene in the rat.
Masayuki Ikeda,Hatsue Ohtsuji +1 more
TL;DR: Rapid disappearance of toLUene from blood due to enhanced hepatic metabolism together with reduced sensitivity of central nervous system offer an explanation for the shortened sleeping time after toluene injection.
References
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Journal Article
Pharmacological implications of microsomal enzyme induction
TL;DR: It is of considerable interest that certain inducers of liver microsomal enzymes have recently been used therapeutically for the treatment of hyperbilirubinemia in jaundiced children and for thetreatment of Cushing's syndrome.
Journal ArticleDOI
Estimation of the ED50 and Its Error by Means of Logarithmic-Probit Graph Paper.∗:
Lloyd C. Miller,M. L. Tainter +1 more
TL;DR: In this paper, a log-probit graph is described by which a simple graphic estimation of the ED50 and its standard error may be quickly made, using a simple graphical model.
Journal Article
MECHANISM OF THE POTENTIATING ACTION OF β-DIETHYLAMINOETHYL DIPHENYLPROPYLACETATE
TL;DR: It is concluded that SKF 525-A prolongs the duration of action of a variety of drugs primarily by inhibiting their rate of metabolic transformation.
Journal ArticleDOI
Benzoyl coenzyme A and hippurate synthesis.
David Schachter,John V. Taggart +1 more
TL;DR: Evidence is presented that benzoyl CoA is utilized directly in the enzymatic synthesis of hippurate, based on the observation of Simon and Shemin that succinyl CoA can be prepared by the interaction of CoA and succinic anhydride.
Journal ArticleDOI
Human exposure to styrene vapor.
TL;DR: The determination of urinary hippuric acid proved to be insensitive as an indicator of exposure to this compound at these vapor concentrations and a measurement of the amount of styrene present in the breath in the early postexposure period provided a means for making an estimation of magnitude of exposure.
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Epoxide intermediates in microsomal oxidation of olefins to glycols
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