Metabolism and toxicity of styrene.
TLDR
Reports of organ toxicity upon chronic exposure to styrene are rare; however, since the chief intermediate in styrene metabolism is an epoxide, hepatotoxicity due to covalent binding at the site of formation appears to be a possibility.Abstract:
The absorption, blood levels, distribution, excretion, and biotransformation of styrene in man and experimental animals are briefly reviewed. The acute toxicity of styrene appears to be unrelated t...read more
Citations
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Review of the toxicology of styrene.
TL;DR: Needed areas of future research on styrene include studies on the molecular dosimetry of styrene in terms of both hemoglobin and DNA adducts, which should improve the ability to assess the relationship between exposure to styrene and surrogate measures of "effective dose", thereby improving the able to estimate the effects of low-level human exposures.
Journal ArticleDOI
The fate of carbon compounds in the landfill disposal of organic matter
TL;DR: The role of refuse pretreatment, placement methods and water management techniques in the control and stimulation of refuse fermentation are also discussed in this paper, where it is concluded that there is no requirement for added nitrogen and phosphorus sources.
Journal ArticleDOI
The role of skin absorption as a route of exposure for volatile organic compounds (vocs) in drinking water
H S Brown,D R Bishop,C A Rowan +2 more
TL;DR: It is concluded that skin absorption of contaminants in drinking water has been underestimated and that ingestion may not constitute the sole or even primary route of exposure.
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Update of the follow-up of mortality and cancer incidence among European workers employed in the vinyl chloride industry.
Elizabeth Ward,Paolo Boffetta,Aage Andersen,Didier Colin,Pietro Comba,James A. Deddens,Marco De Santis,Göran Engholm,Lars Hagmar,Sverre Langård,Ingvar Lundberg,Damien McElvenny,Roberta Pirastu,Davide Sali,Lorenzo Simonato +14 more
TL;DR: Although cirrhosis mortality was decreased overall, there was a trend with cumulative exposure, and no strong relation was observed between cumulative vinyl chloride exposure and other cancers.
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Migration Phenomenon in Food Packaging. Food–Package Interactions, Mechanisms, Types of Migrants, Testing and Relative Legislation—A Review
TL;DR: In this paper, the authors present a review of the main migration phenomena related to the most commonly used packaging materials, which is clearly demonstrated that the complexity of the migration phenomena requires more research to establish internationally accepted risk management procedures and standardised testing methods.
References
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Journal ArticleDOI
Carcinogenicity of Epoxides, Lactones, and Peroxy Compounds
Journal ArticleDOI
Enzymatic Conjugation of Epoxides with Glutathione
TL;DR: Glutathione epoxide transferase has been isolated in homogeneous form from the livers of male Sprague-Dawley rats and several proteins which catalyze the same reaction are demonstrated.
Journal ArticleDOI
An enzyme catalysing the conjugation of epoxides with glutathione.
E Boyland,K Williams +1 more
TL;DR: L Liver supernatant preparations from rats and ferrets catalyse the conjugation of some epoxides with glutathione, which is not inactivated by dialysis but is unstable at pH 5.0.
Journal ArticleDOI
Hydroxylation of aromatic hydrocarbons in the rat
Olav M. Bakke,Ronald R. Scheline +1 more
TL;DR: The hydroxylation of benzene, toluene, ethylbenzene, styrene, cumene, o -xylene, m -xylene, p -Xylene, p-cymene, pseudocumene, and mesitylene was studied following their oral administration to rats to study the formation of phenolic metabolites to the toxicity of aromatic hydrocarbons.
Book
Chemical Induction of Cancer
TL;DR: Govan et al. as mentioned in this paper proposed a method to solve the problem of the lack of medical care in the U.S. Armed Forces by using the concept of kinderheilk.
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