Journal ArticleDOI
The microsomal metabolism of some analogues of cyclophosphamide: 4-methylcyclophosphamide and 6-methylcyclophosphamide.
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TLDR
4-Methylcycloph phosphamide cannot form metabolites analogous to 4-ketocyclophosphamide and carboxyphosphamide, the relatively non-toxic metabolites of cyclophosphamia, and the significance of this fact is discussed in relation to a mechanism which could account for the relatively selective cytotoxicity of cyclophile in vivo towards neoplastic tissue.About:
This article is published in Biochemical Pharmacology.The article was published on 1975-03-01. It has received 27 citations till now. The article focuses on the topics: Methyl vinyl ketone.read more
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Book ChapterDOI
The role of glutathione and glutathione S-transferases in the metabolism of chemical carcinogens and other electrophilic agents.
TL;DR: The knowledge of the way in which mutagens and carcinogens are metabolized is essential to a better understanding of their mode of action and of the processes for their detoxication.
Journal Article
The enzymatic basis of the selective action of cyclophosphamide.
TL;DR: Unpurified aldophosphamide and the analogs prepared from 6-methyl- and 5,5-dimethylcyclophosphamides were substrates for nicotinamide adenine dinucleotide-requiring enzymes, whereas incubation of 4-hydroxy-4-methylcycloph phosphamide in an unfractionated incubation mixture with liver soluble enzymes did not cause reduced nicotinamidine din nucleotide production.
Journal ArticleDOI
Aldehyde dehydrogenase activity as the basis for the relative insensitivity of murine pluripotent hematopoietic stem cells to oxazaphosphorines
Fred R. Kohn,Norman E. Sladek +1 more
TL;DR: Ex vivo sensitivity of murine pluripotent hematopoietic stem cells and myeloid progenitor cells to 4-hydroperoxycyclophosphamide, ASTA Z 7557, phosphoramide mustard, acrolein, melphalan, and cis-platinum was determined and the phenotypic basis for the relative insensitivity of CFU-S to oxazaphosphorines is the aldehyde dehydrogenase activity contained by these cells
Journal Article
Conversion of 4-hydroperoxycyclophosphamide and 4-hydroxycyclophosphamide to phosphoramide mustard and acrolein mediated by bifunctional catalysis.
TL;DR: The observations offer the possibility that the intracellular concentration of bifunctional catalysts, whether in the form of inorganicosphates, organic phosphates, enzymes, or other species, serve as important determinants with regard to the oncotoxic potential and specificity of cyclophosphamide.
References
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Journal ArticleDOI
Some studies of the active intermediates formed in the microsomal metabolism of cyclophosphamide and isophosphamide.
TL;DR: It appeared that, of the known metabolites of cyclophosphamide, only phosphoramide mustard possesses the cytoxicity and biological half-life appropriate to the active antitumour metabolite, and four other metabolites of low cytotoxicity were isolated and identified.
Journal ArticleDOI
Use of γ-(4-Nitrobenzyl)pyridine as Analytical Reagent for Ethylenimines and Alkylating Agents
Journal ArticleDOI
Field desorption mass spectrometry: A technique for the study of thermally unstable substances of low volatility
Journal ArticleDOI
New platinum complexes with anti-tumour activity
TL;DR: A class of compounds have been found which are some thirty to forty times more active against the plasma cell tumour than the platinum complex at present on clinical trial.
Journal ArticleDOI
Field desorption mass spectrometry with high temperature activated emitters
Hans-Rolf Schulten,H.D. Beckey +1 more
TL;DR: In this paper, the use of emitters which have been activated at high temperature in Field Ionization and Field Desorption mass spectrometry offers some important advantages over the usual emitter type activated at room-temperature.