Journal ArticleDOI
The oxygen supply dependency phenomenon is associated with increased blood lactate levels
Jan Bakker,Jean Louis Vincent +1 more
TLDR
An imbalance between oxygen demand and supply is characterized by the oxygen uptake/supply dependency phenomenon and by the development of lactic acidosis, the following analysis of both experimental and clinical studies supports this logical concept.About:
This article is published in Journal of Critical Care.The article was published on 1991-09-01. It has received 59 citations till now. The article focuses on the topics: Anaerobic exercise & Oxygen.read more
Citations
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Journal ArticleDOI
Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine
Maurizio Cecconi,Daniel De Backer,Massimo Antonelli,Richard Beale,Jan Bakker,Christoph Hofer,Roman Jaeschke,Alexandre Mebazaa,Michael R. Pinsky,Jean-Louis Teboul,Jean Louis Vincent,Andrew Rhodes +11 more
TL;DR: In this article, the authors provide support to the bedside clinician regarding the diagnosis, management and monitoring of circulatory shock, which is a life-threatening syndrome resulting in multiorgan failure and a high mortality rate.
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Clinical use of lactate monitoring in critically ill patients
TL;DR: The presence of increased lactate levels has important implications for the morbidity and mortality of the hyperlactataemic patients, and structured lactate measurements should be incorporated in resuscitation protocols.
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Effect of dobutamine on oxygen consumption and gastric mucosal pH in septic patients.
TL;DR: Findings imply that regional tissue hypoxia, as characterized by a low gastric pHi, may be present in septic patients with normal arterial lactate concentration, and that a rise in gastrics pHi in response to increases in systemic O2 transport may be a better indicator of regional hypoxIA in sepsis patients than related increase in systemic VO2.
Journal ArticleDOI
Lactic acidosis in sepsis: a commentary
Guillermo Gutierrez,M. E. Wulf +1 more
TL;DR: The pathogenesis and the management of lactic acidosis in septic patients are subjects of great clinical interest because of the high mortality rates and high uncertainty in the prognosis.
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Cardiorespiratory effects of pressure-controlled ventilation with and without inverse ratio in the adult respiratory distress syndrome.
TL;DR: The results suggest that neither PCV nor PC-IRV bring any benefit over VCV in terms of arterial oxygenation, and the increase in mPaw induced by PC- IRV may be deleterious to the CI and DO2.
References
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Prospective Trial of Supranormal Values of Survivors as Therapeutic Goals in High-Risk Surgical Patients
TL;DR: The hypothesis was proposed that increased CI and DO2 are circulatory compensations for increased postoperative metabolism and this hypothesis was tested in two series, finding that the PA-protocol group mortality was significantly reduced compared with its control group.
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Oxygen utilization and ventilation during exercise in patients with chronic cardiac failure.
TL;DR: It is concluded that the measurement of respiratory gas exchange and air flow during exercise is an objective, reproducible and safe noninvasive method for characterizing cardiac reserve and functional status in patients with chronic cardiac failure.
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Experimental and Clinical Studies on Lactate and Pyruvate as Indicators of the Severity of Acute Circulatory Failure (Shock)
TL;DR: These studies corroborate that L alone serves as a reliable indicator, but neither the measurement of P nor the computation of L/P or XL was shown to improve either the reliability of L as a measure of cumulative oxygen debt or its value as a prognosticator of survival during shock states.
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Blood Lactate Levels Are Superior to Oxygen-Derived Variables in Predicting Outcome in Human Septic Shock
TL;DR: It is concluded that the oxygen-derived variables, Do2 and Vo2, cannot be used as prognostic indicators in human septic shock and, in contrast, blood lactate levels are closely related to ultimate survival from septicshock.
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The Effects of Vasodilation with Prostacyclin on Oxygen Delivery and Uptake in Critically Ill Patients
TL;DR: Data suggest the presence of a substantial oxygen debt in patients who subsequently die, which appears to be an important mechanism contributing to the development of irreversible multiple organ failure and subsequent death in some patients with acute respiratory failure.