Journal ArticleDOI
The pathogenicity of Ab4p, the sequenced strain of equine herpesvirus-1, in specific pathogen-free foals.
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TLDR
Isolation of virus from one foal following intravenous administration of steroids indicates that Ab4p can establish latency and undergo reactivation, and several pathogenic characteristics of Ab4 are retained in the plaque-purified clone, Ab4 p.About:
This article is published in Virology.The article was published on 1992-07-01. It has received 28 citations till now. The article focuses on the topics: Equine herpesvirus 1 & Virus.read more
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Journal ArticleDOI
The trigeminal ganglion is a location for equine herpesvirus 1 latency and reactivation in the horse.
TL;DR: Evidence is presented to show that EHV-1 is neurotropic and, in common with other members of the alpha-herpesvirus subfamily, establishes latency in sensory ganglia from which virus can be reactivated.
Journal ArticleDOI
EHV-1: A Constant Threat to the Horse Industry.
TL;DR: Detailed information on EHV-1 is presented, from the discovery of the virus to latest developments on treatment and control of the diseases it causes, with particular emphasis on viral biology which enables pathogenesis in the natural host.
Journal ArticleDOI
Experimental infection with equine herpesvirus type 1 (EHV-1) induces chorioretinal lesions
Gisela Soboll Hussey,L.S. Goehring,D.P. Lunn,Stephen B. Hussey,Teng Huang,Nikolaus Osterrieder,Cynthia C. Powell,Jesse Hand,Carine Holz,Josh Slater +9 more
TL;DR: The frequency of ocular EHV-1 is 50-90% following experimental infection making this model attractive for testing future vaccines or therapeutics in an immunologically relevant age group and suggest that their pathogenesis may involve ischemic injury to the chorioretina following viremic delivery of virus to the eye, mirroring the vascular events that result in EHM.
Journal ArticleDOI
Comparison of the pathogenesis of acute equine herpesvirus 1 (EHV-1) infection in the horse and the mouse model: a review.
TL;DR: The evidence suggests that the mouse model provides a valid method for investigation of virological and histopathological aspects of EHV-1-induced disease in the horse, but the extent to which useful and valid comparisons and extrapolations can be made of immunological parameters from mouse to horse is yet to be determined.
Journal ArticleDOI
The ORF37 (UL24) is a neuropathogenicity determinant of equine herpesvirus 1 (EHV-1) in the mouse encephalitis model
Samy Kasem,Mi Htay Htay Yu,Souichi Yamada,Akari Kodaira,Tomio Matsumura,Koji Tsujimura,Hanafy Madbouly,Tsuyoshi Yamaguchi,Kenji Ohya,Hideto Fukushi +9 more
TL;DR: The results indicated that the ORF37 is a neuropathogenicity determinant of EHV-1 in the mouse encephalitis model as indicated by the absence of any neurological disorders and death.
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Experimental reactivation of equid herpesvirus 1 (EHV 1) following the administration of corticosteroids.
TL;DR: Eight ponies were experimentally infected with equid herpesvirus 1 (EHV 1) (subtype 1) and five of these six ponies were viraemic and three of them shed virus in nasal secretions; only four displayed significant rises in complement fixing antibody and only two in neutralising antibody.
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Serological Detection of Equid Herpesvirus1 Infections of the Respiratory Tract
TL;DR: Sera from gnotobiotic foals inoculated intranasally with various strains of EHV-1 were unable in some cases to neutralize heterologous strains and these results were not consistent with the existence of clearly-defined subtypes of EhV- 1, as previously proposed.
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Variation in cellular tropism between isolates of equine herpesvirus-1 in foals.
TL;DR: Subtype-1 isolates of Equine herpesvirus-1 from a quadriplegic horse and from an aborted foetus were compared with each other and with a subtype-2 respiratory isolate and replicated in the epithelium of the ileum and correlated with the recovery of virus from faecesin vivo.
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The pathogenesis of equine herpesvirus type 1 in the mouse: a new model for studying host responses to the infection.
TL;DR: The observations suggest that the mouse is a convenient and relevant model in which to study both host responses to EHV-1 infection and modification of the pathogenesis by means of immunoprophylaxis or therapy.
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Trials of an inactivated equid herpesvirus 1 vaccine: challenge with a subtype 1 virus.
R Burrows,D Goodridge,M Denyer +2 more
TL;DR: All vaccinated yearlings and two-year-old ponies developed a febrile respiratory disease but this was less severe than that suffered by the controls and the amounts and duration of virus shedding were reduced.