The pilocarpine model of temporal lobe epilepsy.
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TLDR
It is proposed that the pilocarpine model can be a valuable tool to investigate the mechanisms involved in TLE, and even more so when standardized to reduce mortality at the time of pilocARPine injection, differences in latent period duration, variability in the lesion extent, and SRS frequency.About:
This article is published in Journal of Neuroscience Methods.The article was published on 2008-07-30 and is currently open access. It has received 877 citations till now. The article focuses on the topics: Hippocampal sclerosis & Pilocarpine.read more
Citations
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Journal ArticleDOI
The kainic acid model of temporal lobe epilepsy
TL;DR: It is concluded that the kainic acid model is a reliable tool for understanding temporal lobe epilepsy, provided that the differences existing between methodological procedures are taken into account.
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Prevention or Modification of Epileptogenesis after Brain Insults: Experimental Approaches and Translational Research
Wolfgang Löscher,Claudia Brandt +1 more
TL;DR: Two ongoing clinical trials will address the antiepileptogenic potential of topiramate and levetiracetam in patients with traumatic brain injury, hopefully translating laboratory discoveries into successful therapies.
Journal ArticleDOI
Mechanisms of physiological and epileptic HFO generation.
John G. R. Jefferys,Liset Menendez de la Prida,Fabrice Wendling,Anatol Bragin,Massimo Avoli,Massimo Avoli,Igor Timofeev,Fernando H. Lopes da Silva,Fernando H. Lopes da Silva +8 more
TL;DR: The role of out-of-phase firing in neuronal clusters, the importance of strong excitatory AMPA-synaptic currents and recurrent inhibitory connectivity in combination with the fast time scales of IPSPs, ephaptic coupling and the contribution of interneuronal coupling through gap junctions are considered.
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Blood-brain barrier breakdown-inducing astrocytic transformation: novel targets for the prevention of epilepsy.
TL;DR: It is proposed that primary vascular injury, and specifically BBB breakdown and repair, are key elements in altered interactions within the neurovascular unit and thus may serve as new therapeutic targets.
References
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Modification of seizure activity by electrical stimulation. II. Motor seizure.
TL;DR: It was found that the development of motor seizures by stimulation of the amygdala resulted in an increased ability of the contralateral amygdala, and the septal area, but not of the hippocampus, to drive motor seizures when stimulated (“transfer”).
Book
Epilepsy : a comprehensive textbook
TL;DR: The neurobiology of epilepsy: neuronal excitability experimental modes of epilepsy and the autonomic nervous system comorbidity neuroendocrinology and the delivery of health care and socioeconomic issues.
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Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders.
TL;DR: This review examines the evidence for hippocampal atrophy in Cushing syndrome, which is characterized by a pathologic oversecretion of glucocorticoids; (2) episodes of repeated and severe major depression; (3) posttraumatic stress disorder and what cellular mechanisms underlie the overall decreases in hippocampal volume.
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Limbic seizures produced by pilocarpine in rats: behavioural, electroencephalographic and neuropathological study
Waldemar A. Turski,Esper A. Cavalheiro,Michael P. Schwarz,Stanisław J. Czuczwar,Zdzisław Kleinrok,Lechoslaw Turski +5 more
TL;DR: Results show that systemic pilocarpine in rats selectively elaborates epileptiform activity in the limbic structures accompanied by motor limbic seizures, limbic status epilepticus and widespread brain damage.
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Maturation of the adrenocortical stress response: Neuroendocrine control mechanisms and the stress hyporesponsive period
TL;DR: This work has attempted to explain adrenocortical activity during this period in terms of the unique pattern of glucocorticoid-receptor concentrations that exist in the brain and pituitary of the neonatal rat, which ensures the low, stable corticoid levels that appear to be optimal for neuronal development in glucocortex-sensitive brain regions.