Mechanisms of physiological and epileptic HFO generation.
John G. R. Jefferys,Liset Menendez de la Prida,Fabrice Wendling,Anatol Bragin,Massimo Avoli,Massimo Avoli,Igor Timofeev,Fernando H. Lopes da Silva,Fernando H. Lopes da Silva +8 more
TLDR
The role of out-of-phase firing in neuronal clusters, the importance of strong excitatory AMPA-synaptic currents and recurrent inhibitory connectivity in combination with the fast time scales of IPSPs, ephaptic coupling and the contribution of interneuronal coupling through gap junctions are considered.About:
This article is published in Progress in Neurobiology.The article was published on 2012-03-07 and is currently open access. It has received 269 citations till now. The article focuses on the topics: Ephaptic coupling.read more
Citations
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Hippocampal sharp wave‐ripple: A cognitive biomarker for episodic memory and planning
TL;DR: Alteration of the physiological mechanisms supporting SPW‐Rs leads to their pathological conversion, “p‐ripples,” which are a marker of epileptogenic tissue and can be observed in rodent models of schizophrenia and Alzheimer's Disease.
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EEG and MEG: relevance to neuroscience
TL;DR: The relevance of EEG/MEG signals to obtain novel insights into the neuronal mechanisms underlying cognitive processes is surveyed, with emphasis on neuronal oscillations (ultra-slow, theta, alpha, beta, gamma, and HFOs) and combinations of oscillations.
Journal ArticleDOI
Synchronization and desynchronization in epilepsy: controversies and hypotheses
Premysl Jiruska,Premysl Jiruska,Premysl Jiruska,Marco de Curtis,John G. R. Jefferys,Catherine A. Schevon,Steven J. Schiff,Kaspar Schindler +7 more
TL;DR: Recent work has identified cell‐type‐specific inhibitory and excitatory interactions, the dichotomy between neuronal firing and the non‐local measurement of local field potentials distant to that firing, and the reflection of the neuronal dark matter problem in non‐firing neurons active in seizures.
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Mechanisms of sharp wave initiation and ripple generation.
Dániel Schlingloff,Szabolcs Káli,Tamás F. Freund,Tamás F. Freund,Norbert Hájos,Attila I. Gulyás +5 more
TL;DR: The results suggest that SWRs are initiated through a combined refractory and stochastic mechanism and that the activity of parvalbumin-positive perisomatic inhibitory neurons is both necessary and sufficient for ripple-frequency current and rhythm generation.
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Determinants of different deep and superficial CA1 pyramidal cell dynamics during sharp-wave ripples.
Manuel Valero,Elena Cid,Robert G. Averkin,Juan Aguilar,Alberto Sanchez-Aguilera,Alberto Sanchez-Aguilera,Tim J. Viney,Daniel Gomez-Dominguez,Elisa Bellistri,Liset Menendez de la Prida +9 more
TL;DR: The firing dynamics of hippocampal PCs are exquisitely controlled at subcellular and microcircuit levels in a cell type–selective manner in a deep-superficial gradient interacted with behavioral and spatial effects to determine cell participation during sleep and awake sharp-wave ripples in freely moving rats.
References
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Über das Elektrenkephalogramm des Menschen
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