Journal ArticleDOI
The reaction of (N-isocyanimino)triphenylphosphorane with benzoic acid derivatives : A novel synthesis of 2 -aryl -1,3,4 -oxadiazole derivatives
Ali Souldozi,Ali Ramazani +1 more
TLDR
The reactions of benzoic acid derivatives with (N-isocyanimino)triphenylphosphorane proceed smoothly at room temperature to afford 2-aryl-1,3,4-oxadiazoles in high yields as mentioned in this paper.About:
This article is published in Tetrahedron Letters.The article was published on 2007-02-26. It has received 125 citations till now. The article focuses on the topics: Benzoic acid & Aryl.read more
Citations
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Journal ArticleDOI
To each his own: isonitriles for all flavors. Functionalized isocyanides as valuable tools in organic synthesis
Mariateresa Giustiniano,Andrea Basso,Valentina Mercalli,Alberto Massarotti,Ettore Novellino,Gian Cesare Tron,Jieping Zhu +6 more
TL;DR: All the isocyanides in which the pendant functional group causes either deviation from or reinforces the normal reactivity of the isOCyano group are reviewed and categorized to highlight their common features and differences.
Journal ArticleDOI
Synthetic Approaches and Pharmacological Activity of 1,3,4-Oxadiazoles: A Review of the Literature from 2000–2012
Cledualdo Soares de Oliveira,Bruno Freitas Lira,José Maria Barbosa-Filho,Jorge Goncalo Fernandez Lorenzo,Petrônio Filgueiras de Athayde-Filho +4 more
TL;DR: This review provides readers with an overview of the main synthetic methodologies for 1,3,4-oxadiazole derivatives, and of their broad spectrum of pharmacological activities as reported over the past twelve years.
Journal ArticleDOI
Recent progress of isocyanide-based multicomponent reactions in Iran.
TL;DR: The aim of this review is to provide an overview of the contributions and recent advances made by Iranian scientists in the field of isocyanide-based reactions between 1999 and 2009.
Journal ArticleDOI
Novel one-pot, four-component condensation reaction: an efficient approach for the synthesis of 2,5-disubstituted 1,3,4-oxadiazole derivatives by a Ugi-4CR/aza-Wittig sequence.
Ali Ramazani,Aram Rezaei +1 more
TL;DR: A novel and efficient method has been developed for the synthesis of 2,5-disubstituted 1,3,4-oxadiazole derivatives using (N-isocyanimino)triphenylphosphorane, a secondary amine, a carboxylic acid, and an aromatic aldehyde in CH( 2)Cl(2) in high yields without using any catalyst or activation.
Journal ArticleDOI
Oxadiazole grafts in peptide macrocycles
TL;DR: In this paper, a macrocyclization reaction between a linear peptide, an aldehyde and (N-isocyanimino)triphenylphosphorane was reported.
References
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2-(oxadiazolyl)- and 2-(thiazolyl)imidazo[1,2-a]pyrimidines as agonists and inverse agonists at benzodiazepine receptors.
TL;DR: Replacing the oxadiazole group by thiazole gave compounds such as 23 which binds to the benzodiazepine receptor but exhibits the intrinsic activity of a partial inverse agonist in vivo.
Journal ArticleDOI
Iminophosphoranes: Useful Building Blocks for the Preparation of Nitrogen-Containing Heterocycles
Pedro Molina,M. J. Vilaplana +1 more
Journal ArticleDOI
Synthesis and antibacterial studies of a new series of 1,2-bis(1,3,4-oxadiazol-2-yl)ethanes and 1,2-bis(4-amino-1,2,4-triazol-3-yl)ethanes
TL;DR: The acylhydrazones 3, obtained by the treatment of succinic acid dihydrazide 2 with furfural, nitrofurfuraldehydediacetate and substituted arylfurfurals are found to be active against both Gram positive and Gram negative bacteria at less than 6 microg/mL concentration.
Journal ArticleDOI
Novel procedure for the synthesis of 1,3,4-oxadiazoles from 1,2-diacylhydrazines using polymer-supported burgess reagent under microwave conditions
TL;DR: In this article, a novel and efficient means of effecting the cyclodehydration of 1,2-diacylhydrazines to provide 1,3,4-oxadiazoles was reported.
Journal ArticleDOI
Improved Fischer Indole Reaction for the Preparation of N,N-Dimethyltryptamines: Synthesis of L-695,894, a Potent 5-HT1D Receptor Agonist
Cheng-yi Chen,Chris H. Senanayake,Timothy J. Bill,Robert D. Larsen,Thomas R. Verhoeven,Paul J. Reider +5 more
TL;DR: A highly efficient method for the preparation of N,Ndimethyltryptamines is disclosed with application to the synthesis of L-695,894, which is a potent ~-HTID agonist that is a potential agent for migraine the rap.
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Novel one-pot, four-component condensation reaction: an efficient approach for the synthesis of 2,5-disubstituted 1,3,4-oxadiazole derivatives by a Ugi-4CR/aza-Wittig sequence.
Ali Ramazani,Aram Rezaei +1 more