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Yvonne Loong
Researcher at Novartis
Publications - 4
Citations - 353
Yvonne Loong is an academic researcher from Novartis. The author has contributed to research in topics: Cannabinoid receptor & Burgess reagent. The author has an hindex of 3, co-authored 4 publications receiving 340 citations.
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Journal ArticleDOI
Novel procedure for the synthesis of 1,3,4-oxadiazoles from 1,2-diacylhydrazines using polymer-supported burgess reagent under microwave conditions
TL;DR: In this article, a novel and efficient means of effecting the cyclodehydration of 1,2-diacylhydrazines to provide 1,3,4-oxadiazoles was reported.
Journal ArticleDOI
Naphthalen -1 -yl -(4 -pentyloxynaphthalen -1 -yl)methanone : A potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration
Edward K. Dziadulewicz,Stuart Bevan,Christopher Thomas Brain,Paul R. Coote,Andrew James Culshaw,Andrew J. Davis,Lee Edwards,Adrian J. Fisher,Alyson Fox,Clive Gentry,Alex Groarke,Hart Terance William,Werner Huber,Iain F. James,Adam Kesingland,Luigi La Vecchia,Yvonne Loong,Isabelle Lyothier,Kara McNair,† Cathal O'Farrell,Marcus Peacock,Portmann Robert,Ulrich Schopfer,and Mohammed Yaqoob,Jiri Zadrobilek +24 more
TL;DR: A new class of cannabinoid ligands was rationally designed from known aminoalkylindole agonists and showed good binding and functional activities at human CB1 and CB2 receptors, which led to the discovery of a novel CB1/CB2 dual agonist, naphthalen-1-yl-(4-pentyloxynaphthalanone), which displays good oral bioavailability, potent antihyperalgesic activity in animal models, and limited brain penetration.
Journal ArticleDOI
Antihyperalgesic properties of the cannabinoid CT-3 in chronic neuropathic and inflammatory pain states in the rat
Alex Dyson,Marcus Peacock,Alice Chen,Jean-Philippe Courade,Mohammed Yaqoob,Alex Groarke,Christopher Thomas Brain,Yvonne Loong,Alyson Fox +8 more
TL;DR: Data show that CT‐3 is a cannabinoid receptor agonist and is efficacious in animal models of chronic pain by activation of the CB1 receptor, and exhibits a superior therapeutic index compared to other cannabinoid compounds, which may reflect a relatively reduced CNS penetration.
Journal ArticleDOI
Novel Procedure for the Synthesis of 1,3,4-Oxadiazoles from 1,2-Diacylhydrazines Using Polymer-Supported Burgess Reagent under Microwave Conditions.
TL;DR: In this article, a novel and efficient means of effecting the cyclodehydration of 1,2-diacylhydrazines to provide 1,3,4-oxadiazoles was reported.