Journal ArticleDOI
The Regulation of Neural Precursor Cells within the Mammalian Brain
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This article is published in Molecular and Cellular Neuroscience.The article was published on 1995-02-01. It has received 98 citations till now. The article focuses on the topics: Neurosphere & Neuroepithelial cell.read more
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Single factors direct the differentiation of stem cells from the fetal and adult central nervous system.
TL;DR: A simple model in which transient exposure to extrinsic factors acting through known pathways initiates fate decisions by multipotential CNS stem cells is supported.
Journal ArticleDOI
Timing of CNS Cell Generation: A Programmed Sequence of Neuron and Glial Cell Production from Isolated Murine Cortical Stem Cells
Xueming Qian,Qin Shen,Susan K. Goderie,Wenlei He,Alexandra Capela,Andrew A. Davis,Sally Temple +6 more
TL;DR: It is shown that isolated stem cells from the embryonic mouse cerebral cortex exhibit a distinct order of cell-type production: neuroblasts first and glioblasts later, accompanied by changes in their capacity to make neurons versus glia and in their response to the mitogen EGF.
Journal ArticleDOI
Multipotent progenitor cells in the adult dentate gyrus
TL;DR: Although multipotent stem cells exist in the adult rodent dentate gyrus, their biological significance remains elusive.
Journal ArticleDOI
FGF2 concentration regulates the generation of neurons and glia from multipotent cortical stem cells.
TL;DR: The embryonic cerebral cortex contains a population of stem-like founder cells capable of generating large, mixed clones of neurons and glia in vitro, and it is reported that the default state of early cortical stem cells is neuronal and that stem cells are heterogeneous in the number of neurons that they generate.
Journal ArticleDOI
The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis
Nadia Dahmane,Nadia Dahmane,Pilar Sanchez,Pilar Sanchez,Yorick Gitton,Yorick Gitton,Verónica Palma,Verónica Palma,Tao Sun,Tao Sun,Mercedes Beyna,Mercedes Beyna,Howard L. Weiner,Howard L. Weiner,Ariel Ruiz i Altaba,Ariel Ruiz i Altaba +15 more
TL;DR: In vitro and in vivo assays show that SHH is a mitogen for neocortical and tectal precursors and that it modulates cell proliferation in the dorsal brain and that misexpression of GLI1 induces CNS hyperproliferation that depends on the activation of endogenous Gli1 function.
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Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system
Brent A. Reynolds,Samuel Weiss +1 more