The relationship between survival time and dosage with certain toxic agents.
George E. P. Box,H. Cullumbine +1 more
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This article is published in British journal of pharmacology and chemotherapy.The article was published on 1947-03-01 and is currently open access. It has received 12 citations till now.read more
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The Estimation of Response-Time Distributions. I. Fundamental Concepts and General Methods
Journal ArticleDOI
The use of survival time in the analysis of neutralization tests for serum antibody surveys.
C. E. G. Smith,D. R. Westgarth +1 more
TL;DR: Using the survival times of the mice, a method of analysis has been devised which enables comparisons to be made between tests involving widely different doses of virus.
Journal ArticleDOI
Survival time as a rapid method of determining virulence with Bacillus anthracis.
TL;DR: Sampford as discussed by the authors used median survival time (STGo) of the animals in a given treatment as a measure of virulence with Bacillus anthracis, which can be obtained in 1 day by the method described in this paper.
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Exposure-response effects of inhaled sulfur mustard in a large porcine model: a 6-h study
Sarah Fairhall,Bronwen Jugg,Robert W. Read,S. J. Stubbs,Steve Rutter,A. J. Smith,T. M. Mann,John Jenner,Alfred M. Sciuto +8 more
TL;DR: Findings are consistent with those seen in the early stages of acute lung injury (ALI), including necrosis and erosion of the tracheal epithelium in medium and high HD-exposed groups.
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Preliminary Studies of Sulphur Mustard–Induced Lung Injury in the Terminally Anesthetized Pig: Exposure System and Methodology
TL;DR: A system is described that allows reproducible exposure of HD vapor to the lung of anesthetized white pigs and has proved to be robust and reliable and will be a valuable tool in assessing potential future therapies against HD-induced lung injury in the pig.
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The calculation of the time‐mortality curve
C. I. Bliss,W. L. Stevens +1 more
TL;DR: By means of the truncated time-mortality curve the toxicological value of studies on the reaction time can be extended considerably and the effect of grouping upon these calculations is discussed with particular reference to developing an efficient experimental design.
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The statistical treatment of toxicological data relating to ore than one dosage factor
TL;DR: It is shown that probit regression planes and hyper-planes can be fitted in a way exactly analogous to that used for the regression line, and the notion of relative potency of two poisons does not extend so easily, and it is suggested that the mean probit difference should be used in its stead as a measure of their relative effectiveness.