Journal ArticleDOI
The relationship between the level of plasma B-type natriuretic peptide and mitral stenosis
Namık Kemal Eryol,Ali Dogan,Ibrahim Ozdogru,Mehmet Tugrul Inanc,Mehmet Gungor Kaya,Nihat Kalay +5 more
TLDR
It is ascertained that the level of plasma BNP and the degree of MS are significantly correlated, and as MS becomes more serious, the plasma B NP level rises.Abstract:
B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) are both secreted primarily from the ventricle myocardium in response to the increase in volume and pressure. We aimed to investigate the relationship between the severity of mitral stenosis (MS) and the level of plasma BNP. A total of 56 patients (50 female, 6 male) were included in the study. Mitral stenosis and its related parameters were evaluated by echocardiographic methods. Patients were divided into three groups as with mild, moderate and severe MS according to their planimetric valvular area. Plasma BNP levels were measured using “Triage-B-type natriuretic peptide test” method (Biosite Diagnostics, San Diego). The relationship of BNP with mitral stenosis and other echocardiographic parameters were studied. The comparison of the 3 groups with one another revealed that the BNP level in the group with moderate MS was higher than that in the group with mild MS, however it was statistically insignificant (74.9 ± 49.7 versus 49.9 ± 40.5 pg/ml, p > 0.05). BNP level in the group with severe MS was significantly higher than that in the mild MS (144.3 ± 83.9 versus 49.9 ± 40.5 pg/ml, p < 0.001) and that in the moderate MS group (144.3 ± 83.9 versus. 74.9 ± 49.7 pg/ml, p < 0.05). When patients were taken together, as the area of the mitral valve decreased, the level of BNP underwent a corresponding increase (r:−0.48, p < 0.001). We have ascertained that the level of plasma BNP and the degree of MS are significantly correlated, and as MS becomes more serious, the plasma BNP level rises.read more
Citations
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Journal ArticleDOI
The role of biomarkers in valvular heart disease: focus on natriuretic peptides.
TL;DR: In this paper, the value of natriuretic peptide measurements in valve disease was reviewed and the authors concluded that very high BNP values are associated with increased mortality and should lead to close monitoring peri-and post-operatively.
Journal ArticleDOI
Brain natriuretic peptide predicts right heart failure in patients with acute pulmonary embolism
S. Kruger,J. Graf,M.W. Marx +2 more
Journal ArticleDOI
Factors associated with the development of atrial fibrillation in patients with rheumatic mitral stenosis
Mehmet Ozaydin,Yasin Türker,Ercan Varol,Sule Alaca,Dogan Erdogan,Nigar Yilmaz,Abdullah Dogan +6 more
TL;DR: High sensitivity C reactive protein, N-terminal of brain natriuretic peptide precursor and left atrial diameter are associated with development AF in patients with MS according to their rhythm in the baseline ECG.
Journal ArticleDOI
Comparison of Atrial and Brain Natriuretic Peptide for the Assessment of Mitral Stenosis
Vishal Sharma,Vishal Sharma,Ralph A.H. Stewart,Irene Zeng,Christopher Raffel,Christopher Raffel,Andrew Kerr +6 more
TL;DR: BNP may improve risk stratification of patients with MS, particularly when symptoms are equivocal, and ANP did not provide additional predictive information to BNP.
Journal ArticleDOI
Serum biomarkers in valvular heart disease.
TL;DR: As the prevalence of VHD increases, it will be increasingly important to develop the understanding of the factors that determine the rate of progression (allowing the planning of careful and efficient follow-up and timely intervention).
References
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Journal ArticleDOI
Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure.
Alan S. Maisel,Padma Krishnaswamy,Richard M. Nowak,James McCord,Judd E. Hollander,Philippe Duc,Torbjørn Omland,Alan B. Storrow,William T. Abraham,Alan H.B. Wu,Paul Clopton,Philippe Gabriel Steg,Arne Westheim,Catherine W. Knudsen,Alberto Perez,Radmila Kazanegra,Howard C. Herrmann,Peter A. McCullough +17 more
TL;DR: Used in conjunction with other clinical information, rapid measurement of B-type natriuretic peptide is useful in establishing or excluding the diagnosis of congestive heart failure in patients with acute dyspnea.
Journal ArticleDOI
Plasma brain natriuretic peptide concentration: impact of age and gender.
Margaret M. Redfield,Richard J. Rodeheffer,Steven J. Jacobsen,Douglas W. Mahoney,Kent R. Bailey,John C. Burnett +5 more
TL;DR: Investigation of the effects of age and gender on plasma brain natriuretic peptide concentration in a population-based study confirmed that discriminatory values for BNP for detection of reduced ejection fraction were higher in women and older persons and were different between the two assays.
Journal ArticleDOI
Utility of B-type natriuretic peptide in the diagnosis of congestive heart failure in an urgent-care setting.
Quyen Dao,Padma Krishnaswamy,Radmila Kazanegra,Alex Harrison,Rambod Amirnovin,Leslie A. Lenert,Paul Clopton,Joel Alberto,Patricia Hlavin,Alan S. Maisel +9 more
TL;DR: B-type natriuretic peptide blood concentration measurement appears to be a sensitive and specific test to diagnose CHF in urgent-care settings.
Journal ArticleDOI
Plasma Brain Natriuretic Peptide Levels Increase in Proportion to the Extent of Right Ventricular Dysfunction in Pulmonary Hypertension
Noritoshi Nagaya,Toshio Nishikimi,Yoshiaki Okano,Masaaki Uematsu,Toru Satoh,Shingo Kyotani,Sachio Kuribayashi,Seiki Hamada,Mikio Kakishita,Norifumi Nakanishi,Makoto Takamiya,Takeyoshi Kunieda,Hisayuki Matsuo,Kenji Kangawa +13 more
TL;DR: Plasma BNP increases in proportion to the extent of RV dysfunction in pulmonary hypertension, and the BNP/ANP ratio was significantly higher in patients with RVPO than with RVVO.
Journal ArticleDOI
Plasma natriuretic peptides for community screening for left ventricular hypertrophy and systolic dysfunction: the Framingham heart study.
Ramachandran S. Vasan,Emelia J. Benjamin,Emelia J. Benjamin,Martin G. Larson,Martin G. Larson,Eric P. Leip,Thomas J. Wang,Thomas J. Wang,Peter W.F. Wilson,Peter W.F. Wilson,Daniel Levy,Daniel Levy,Daniel Levy +12 more
TL;DR: In this large community-based sample, the performance of BNP and NT-ANP for detection of elevated LV mass and LVSD was suboptimal, suggesting limited usefulness of natriuretic peptides as mass screening tools.