Journal ArticleDOI
The role of asymmetric and symmetric dimethylarginines in renal disease
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TLDR
Current available data from prospective clinical trials in patients with chronic kidney disease suggest that ADMA is an independent marker of progression of renal dysfunction, vascular complications and death, and the biochemical pathways that regulate ADMA and SDMA and the pathways that transduce their biological function could be targeted to treat renal disease in the future.Abstract:
Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthases. By inhibiting nitric oxide formation, ADMA causes endothelial dysfunction, vasoconstriction, elevation of blood pressure, and aggravation of experimental atherosclerosis. Levels of ADMA and its isomer symmetric dimethylarginine (SDMA), which does not inhibit nitric oxide synthesis, are both elevated in patients with kidney disease. Currently available data from prospective clinical trials in patients with chronic kidney disease suggest that ADMA is an independent marker of progression of renal dysfunction, vascular complications and death. High SDMA levels also negatively affect survival in populations at increased cardiovascular risk, but the mechanisms underlying this effect are currently only partly understood. Beyond glomerular filtration, other factors influence the plasma concentrations of ADMA and SDMA. Elevated plasma concentrations of these dimethylarginines might also indirectly influence the activity of nitric oxide synthases by inhibiting the uptake of cellular L-arginine. Other mechanisms may exist by which SDMA exerts its biological activity. The biochemical pathways that regulate ADMA and SDMA, and the pathways that transduce their biological function, could be targeted to treat renal disease in the future.read more
Citations
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Arginine Metabolism Revisited.
TL;DR: Although much is known about arginine metabolism, elucidation of the physiologic or pathophysiologic roles for all of the pathways and their metabolites remains an active area of investigation, as exemplified by current findings highlighted in this review.
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Biochemical and Clinical Impact of Organic Uremic Retention Solutes: A Comprehensive Update
TL;DR: The inflammatory, cardio-vascular and fibrogenic systems were those most frequently affected and they are one by one major actors in the high morbidity and mortality of CKD but also the mechanisms that have most frequently been studied.
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TL;DR: In this paper, the link between CKD and CVD was explored and interventional advice where available, while exposing the current lack of RCT-based research and trial evidence in this area.
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Comparison of serum concentrations of symmetric dimethylarginine and creatinine as kidney function biomarkers in cats with chronic kidney disease.
TL;DR: Using serum SDMA as a biomarker for CKD allows earlier detection of CKD in cats compared with sCr, which may be desirable for initiating renoprotective interventions that slow progression of CKC.
References
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Journal ArticleDOI
Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure.
TL;DR: In-vitro and in-vivo evidence that NO synthesis can be inhibited by an endogenous compound, NG,NG-dimethylarginine, ADMA is described, which might contribute to the hypertension and immune dysfunction associated with chronic renal failure.
Journal ArticleDOI
Protein Arginine Methylation in Mammals: Who, What, and Why
Mark T. Bedford,Steven Clarke +1 more
TL;DR: Physiological roles for protein arginine methylation have been established in signal transduction, mRNA splicing, transcriptional control, DNA repair, and protein translocation.
Journal ArticleDOI
Asymmetric Dimethylarginine (ADMA): A Novel Risk Factor for Endothelial Dysfunction Its Role in Hypercholesterolemia
Rainer H. Böger,Stefanie M. Bode-Böger,Andrzej Szuba,Philip S. Tsao,Jason R. Chan,Oranee Tangphao,Terrence F. Blaschke,John P. Cooke +7 more
TL;DR: Elevation of ADMA is associated with impaired endothelium-dependent vasodilation and reduced urinary nitrate excretion and this abnormality is reversed by administration of L-arginine.
Journal ArticleDOI
Plasma concentration of asymmetrical dimethylarginine and mortality in patients with end-stage renal disease: A prospective study
Carmine Zoccali,Stefanie M. Bode-Böger,Francesca Mallamaci,F. Benedetto,Giovanni Tripepi,Lorenzo Malatino,Alessandro Cataliotti,Ignazio Bellanuova,Isabella Fermo,Jürgen C. Frölich,Rainer H. Böger +10 more
TL;DR: In haemodialysis patients, plasma ADMA is a strong and independent predictor of overall mortality and cardiovascular outcome, and lends support to the hypothesis that accumulation of AD MA is an important risk factor for cardiovascular disease in chronic renal failure.