Journal ArticleDOI
The significance of 5'-nucleotide phosphodiesterase isozymes in the diagnosis of liver carcinoma.
TLDR
The results of determination of the serum 5′‐NPDase isozymes in 95 cases of primary liver carcinoma and other kinds of liver disase are presented and this test might be a useful supplement to AFP determination, especially in AFP‐negative liver cancer patients.Abstract:
The results of determination of the serum 5'-NPDase isozymes in 95 cases of primary liver carcinoma and other kinds of disease are presented. The 5'-NPDase-V was positive in 83.2% of primary liver cancer cases. This test might be a useful supplement to AFP determination, especially in AFP-negative liver cancer patients. In most patients who had undergone successful liver resection for primary carcinoma, the test became negative. A positive 5'NPDase-V test in patients with cancer elsewhere in the body may suggest liver metastasis. In addition, this test may be of some help in the differentiation of primary liver cancer from other kinds of liver disease. The problem of "false-positive" results of this test is discussed.read more
Citations
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Journal ArticleDOI
National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines for Use of Tumor Markers in Liver, Bladder, Cervical, and Gastric Cancers
Catharine M. Sturgeon,Michael J. Duffy,Barry R. Hofmann,Rolf Lamerz,Herbert A. Fritsche,Katja N. Gaarenstroom,Johannes M.G. Bonfrer,Thorsten H. Ecke,H. Barton Grossman,Peter C. Hayes,Ralf-Thorsten Hoffmann,Seth P. Lerner,Florian Löhe,Johanna Louhimo,Ihor S. Sawczuk,Kazuhisa Taketa,Eleftherios P. Diamandis +16 more
TL;DR: Alpha-fetoprotein (AFP) may be used in conjunction with abdominal ultrasound for early detection of hepatocellular carcinoma (HCC) in patients with chronic hepatitis or cirrhosis associated with hepatitis B or C virus infection.
Journal ArticleDOI
Distribution of phosphodiesterase I in normal human tissues
TL;DR: The widespread epithelial distribution of immunoreactive PDE I detected by this polyclonal antibody implies an integral role in cell function, probably in active transport.
Journal ArticleDOI
5'-nucleotide phosphodiesterase isozyme-V as a marker for liver metastases in breast cancer patients
TL;DR: A 2‐year prospective study testing 258 breast cancer patients for the presence of 5′‐nucleotide phosphodiesterase isozyme‐V (5′‐NPD‐V) as a marker for liver metastases concluded that this test is more specific than other liver function tests.
Journal ArticleDOI
Flow cytometric DNA and 5'-nucleotide phosphodiesterase in endometrium.
K. C. Tsou,K. C. Tsou,Dai‐Hwa ‐H Hong,Michael A. Varello,James E. Wheeler,Robert L. Giuntoli,Charles E. Mangan,John J. Mikuta +7 more
TL;DR: Evidence is provided for the first time evidence that this exonuclease activity alters in the cell cycle fractions and that a decrease in the enzyme activity in G0/G1 cells and an increase in G2/M cells may be a useful marker for neoplastic development in human endometrial cancer.
Journal ArticleDOI
Tissue specificity of human phosphodiesterase. I. Blood serum
TL;DR: Human blood serum was found to contain two enzymes which hydrolyze various phosphate diester and phosphonate ester bonds and zymograms showed that one of these enzymes is serum alkaline phosphatase and the other is a 'true' phosphodiesterase I.
References
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Journal Article
5′-Nucleotide Phosphodiesterase Isoenzyme Pattern in the Serum of Human Hepatoma
K. C. Tsou,S. Ledis,M. G. McCoy +2 more
TL;DR: All six cases of hepatoma sera from patients having histologically identified primary hepatoma show an additional, fast-moving isoenzyme band compared to normal serum, and a benign liver adenoma serum shows no such additional isoen enzyme band.
Journal ArticleDOI
Serum 5'--nucleotide phosphodiesterase isozyme--V test for human liver cancer.
K. C. Tsou,K. W. Lo +1 more
TL;DR: 5′‐NPDase‐V test is a sensitive and an important diagnostic aid for cancer patients, both as an early predictor for liver metastases, and a useful marker for primary hepatoma when no other primary sites are found and when there is no evidence of severe chronic liver disease such as cirrhosis.
Journal ArticleDOI
A new indigogenic method for the light and electron microscopic demonstration of 5'-nucleotide phosphodiesterases.
TL;DR: In regenerated liver and hepatoma, activity can also be seen associated with the nuclear envelope, and the distribution of this phosphodiesterase is different from that of the acid and alkaline monophosphoesterase.
Journal Article
5'-Nucleotide phosphodiesterase activity in rat hepatoma.
TL;DR: It is indicated that 5′-nucleotide phosphodiesterase change may be relevant to the growth patterns of hepatoma and extension of this approach to other animal tumors and human neoplasm should therefore be of interest.
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Serum 5'--nucleotide phosphodiesterase isozyme--V test for human liver cancer.
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