Journal ArticleDOI
The Stability and Screw Sense of the α-Helix in Poly-β-Benzyl-L-Aspartate
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TLDR
A number of polymers and copolymers containing β-benzyl-L-aspartate have been prepared and their optical rotatory dispersion in a variety of solvents has been measured as mentioned in this paper.Abstract:
A number of polymers and copolymers containing $\beta$-benzyl-L-aspartate has been prepared and their optical rotatory dispersion in a variety of solvents has been measured. The results of these measurements together with studies of infra-red spectra, X-ray diffraction patterns, deuteration rates and molecular models lead to the following conclusions. (i) The $\alpha$-helical form of poly-$\beta$-benzyl-L-aspartate is considerably less stable relative to the solvated randomly coiled form than that of poly-$\gamma$-benzyl-L-glutamate. (ii) The left-handed $\alpha$-helix of poly-$\beta$-benzyl-L-aspartate is more stable than the right-handed one. (iii) The difference in stability between the two senses of $\alpha$-helix is much less in the case of poly-$\beta$-benzyl-L-aspartate than in that of poly-$\gamma$-benzyl-L-glutamate or poly-L-alanine.read more
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Book ChapterDOI
Conformation of Polypeptides and Proteins
TL;DR: This chapter considers the parameters that are required for an adequate description of a polypeptide chain and the mathematical method of utilizing these parameters for calculating the coordinates of all the atoms in a suitable frame of reference so that all the interatomic distances, and bond angles, can be calculated and their consequences worked out.
Book ChapterDOI
Optical rotation and the conformation of polypeptides and proteins.
Peter Urnes,Paul Doty +1 more
TL;DR: An extension of the spectral range of measurement toward optically active absorption bands in the far ultraviolet is expected to yield new information about the rotatory power of the peptide bond and thus enhance the interaction of theory and observation that has already proved fruitful.
Journal ArticleDOI
Optical Rotation of Oriented Helices. III. Calculation of the Rotatory Dispersion and Circular Dichroism of the Alpha‐ and 310‐Helix
Robert W. Woody,Ignacio Tinoco +1 more
TL;DR: In this article, an analysis of the calculated ORD curves according to the Moffitt-Yang and Shechter-Blout procedures leads to values for the parameters in these equations which agree well with experiment in the case of the α-helix.
Journal ArticleDOI
The structure of the ω-form of poly-β-benzyl-L-aspartate
TL;DR: In this article, the preparation of oriented films and fibres of poly- β -benzyl- L -aspartate in the α-helical and ω-forms is described, along with their examination by polarized infrared radiation and by X-ray diffraction.
Journal ArticleDOI
Conformational Analysis of Macromolecules. V. Helical Structures of Poly‐L‐aspartic Acid and Poly‐L‐glutamic Acid, and Related Compounds
TL;DR: The computed helix sense was found to agree with the experimental one in all cases except one, using a single set of potential functions and parameters, and the various contributions to the total energy are all important in their influence on the conformation.
References
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Journal ArticleDOI
The structure of proteins; two hydrogen-bonded helical configurations of the polypeptide chain.
TL;DR: This work has used information about interatomic distances, bond angles, and other configurational parameters to construct two reasonable hydrogen-bonded helical configurations for the polypeptide chain; it is likely that these configurations constitute an important part of the structure of both fibrous and globular proteins, as well as of syntheticpolypeptides.
Journal ArticleDOI
Optical Rotatory Dispersion of Helical Polymers
TL;DR: In this paper, it was shown that for every transition in its individual residues, a helix has two transitions whose moments are respectively parallel and perpendicular to the screw axis, and that the largest contributions to the rotational strengths of these bands are equal and opposite in the two cases.