Journal ArticleDOI
The synthesis of pyrimido[4,5-c] pyridazines and pyrido[2,3-d]pyrimidines related to toxoflavin and fervenulin
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TLDR
In this paper, 4-deazatoxoflavin and 4deazafervenulin analogs have been prepared with the required intermediates, including 3,5,7-trimethyl-1,2,3,4,4-tetrahydropyrido[2, 3,d]-2, 4-pyrimidinedione.About:
This article is published in Journal of Heterocyclic Chemistry.The article was published on 1975-12-01. It has received 21 citations till now. The article focuses on the topics: Toxoflavin.read more
Citations
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Book ChapterDOI
Uracils: Versatile Starting Materials in Heterocyclic Synthesis
TL;DR: This chapter provides a brief review on uracil and its chemistry and has pointed out by some selective but typical examples that show uracils and their derivatives possess considerable synthetic potential.
Journal ArticleDOI
Regiospecific one-pot synthesis of pyrimido[4,5-d]pyrimidine derivatives in the solid state under microwave irradiations.
TL;DR: This procedure provides a convenient method for the direct synthesis of pyrimido[4,5-d]pyrimidines in excellent yields when carried out in the solid state and under microwave irradiations.
Journal ArticleDOI
PLK1 as a potential drug target in cancer therapy
Kee Chuan Goh,Haishan Wang,Niefang Yu,Yifa Zhou,Yin Zheng,Ze-Yi Lim,Kanda Sangthongpitag,Lijuan Fang,Mark X. Du,Xukun Wang,Anne B. Jefferson,Janet Rose,Blanche Shamoon,Christoph Reinhard,Brad Carte,Michael Entzeroth,BinHui Ni,Marcia L. Taylor,Walter Stünkel +18 more
TL;DR: The data suggest that PLK1 may serve as a target for discovering small molecule anticancer agents, and low micromolar antiproliferative activity towards SW620, a human colon cancer cell line, most likely through cell cycle arrest at the G2/M phase.
Journal ArticleDOI
A novel synthesis of 3-(substituted)pyrimido[4,5-c]pyridazine-5,7(1H,6H)-diones
TL;DR: An improved synthesis of 3-(substituted)pyrimido[4,5-c]pyridazine-5,7(1H,6H)-diones, a known subclass of 4-deazatoxoflavins, is reported.
Journal ArticleDOI
A Novel Synthesis of Fused Uracils: Indenopyrimidopyridazines, Pyrimidopyridazines, and Pyrazolopyrimidines for Antimicrobial and Antitumor Evalution
TL;DR: A variety of different compounds of fused uracils were prepared simply by the heating of 6-hydrazinyl-1-methyl-, 6-Hydrazinyl -1-propyl-, or 6- Hydrazinyl, 1,3-dipropyluracil under reflux with ninhydrin, isatin, benzylidene malononitrile, benzylylidene ethyl cyanoacetate, benzil, and phenacyl brom
References
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Journal ArticleDOI
On the origin of the toxicity of toxoflavin.
H.E. Latuasan,W. Berends +1 more
TL;DR: The mechanism of action of toxoflavin appears to act as an electron-carrier which makes possible a by-passing of the cytochrome-system and the final result of this electron-transfer is the production of hydrogen-peroxide.
Journal ArticleDOI
Studies on Condensed Pyrimidine Systems. XIX. A New Synthesis of Pyrido [2,3-d] pyrimidines. The Condensation of 1,3-Diketones and 3-Ketoaldehydes with 4-Aminopyrimidines
Journal ArticleDOI
Antibiotics. I. Synthesis of 1,6-Dimethyl-5,7-dioxo-1,5,6,7-tetrahydropyrimido [5,4-e] as-Triazine (Toxoflavin) and Related Compounds
Journal ArticleDOI
Studies on Condensed Pyrimidine Systems. XII. Synthesis of Some 4- and 2,4-Substituted Pyrido[2,3-d]pyrimidines
Journal ArticleDOI
On toxoflavin, the yellow poison of pseudomonas cocovenenans
TL;DR: In this article, a new investigation of the structure of Pseudomonas cocovenenans was carried out, leading to an entirely different structure and simplified the isolation of toxoflavin.