Journal ArticleDOI
The use of carbamates and atropine in the protection of animals against poisoning by 1,2,2-trimethylpropyl methylphosphonofluoridate
W.K. Berry,D.R. Davies +1 more
TLDR
Physostigmine plus atropine gave rather more protection to guinea pigs against Sarin but not so much as was given by P2S (2-hydroxyiminomethyl-N-methylpyridinium methanesulphonate) and atropines.About:
This article is published in Biochemical Pharmacology.The article was published on 1970-03-01. It has received 195 citations till now. The article focuses on the topics: Physostigmine & Sarin.read more
Citations
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Neuropharmacological Mechanisms of Nerve Agent-induced Seizure and Neuropathology
TL;DR: In this article, a three phase "model" of the neuropharmacological processes responsible for the seizures and neuropathology produced by nerve agent intoxication is proposed, and the model and data indicate that rapid and aggressive management of seizures is essential to prevent neuropathological from nerve agent exposure.
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The protection of animals against organophosphate poisoning by pretreatment with a carbamate.
TL;DR: Guinea pigs responded better than rabbits, whereas rats were virtually unresponsive, suggesting that many factors are involved in determining their protective action in addition to their ability to inhibit tissue acetylcholinesterase reversibly.
Journal ArticleDOI
Control of nerve agent-induced seizures is critical for neuroprotection and survival
TL;DR: Seizure control was strongly associated with protection against acute lethality and brain pathology, and midazolam was more rapid in controlling seizure than atropine, trihexyphenidyl, or diazepam against each agent.
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The protection of primates against soman poisoning by pretreatment with pyridostigmine
TL;DR: The effectiveness of pyridostigmine pretreatment against soman poisoning has been determined in rhesus monkeys and marmosets receiving atropine therapy, and levels of protection are higher than any reported in non‐primate species.
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Treatment of poisoning by soman
TL;DR: It is concluded that a number of different pharmacological actions are required to antagonize nerve agent-induced incapacitation and that they, and their relative importance, remain to be identified.
References
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Journal ArticleDOI
Carbamylation of acetvlcholinesterase.
Journal ArticleDOI
Carbamyl derivatives of acetylcholinesterase.
TL;DR: A more complicated reaction occurs than the formation of a reversible complex as one envisages in the case of reversible competitive inhibitors, and a slow return of activity upon dilution is demonstrated and the rate is increased by hydroxylamine.
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Toxogonin in sarin, soman and tabun poisoning.
Edith Heilbronn,Birgitta Tolagen +1 more
TL;DR: The oximes P2S, TMB-4 and Toxogonin have been tested as reactivators of Sarin and Tabun inhibited acetylcholinesterase and the protective effect of the oximes has been studied on atropinized mice in experimental Sarin, Soman andTabun poisoning.
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On an approximate method of determining the median effective dose and its error, in the case of a quantal response.
J. O. Irwin,E. A. Cheeseman +1 more
TL;DR: Käber's method is, for many purposes, a sufficiently accurate way of determining the median effective dose, when the authors have a series of doses increasing in a constant ratio and a small number of animals on each.
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Antidotal action of pyridinium oximes in anticholinesterase poisoning; comparative effects of soman, sarin, and neostigmine on neuromuscular function.
Ted A. Loomis,B. Salafsky +1 more
TL;DR: The oximes do not appear to be effective adjuvants to atropine in poisoning with the anticholinesterase agent soman and with the comparative effectiveness of some oximes on the effects of soman, sarin, and neostigmine.