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Journal ArticleDOI

Theory and Experiment for the Effect of Vascular Microstructure on Surface Tissue Heat Transfer—Part II: Model Formulation and Solution

TLDR
A closed form analytic solution for the boundary value problem coupling the three layers is obtained in terms of numerically evaluated integrals describing the detailed vascular geometry, a capillary bleed-off distribution function and parameters describing the shunting of blood to the cutaneous layer.
Abstract
In this paper the conceptual three-layer representation of surface tissue heat transfer proposed in Weinbaum, Jiji and Lemons [1], is developed into a detailed quantitative model. This model takes into consideration the variation of the number density, size and flow velocity of the countercurrent arterio-venous vessels as a function of depth from the skin surface, the directionality of blood perfusion in the transverse vessel layer and the superficial shunting of blood to the cutaneous layer. A closed form analytic solution for the boundary value problem coupling the three layers is obtained. This solution is in terms of numerically evaluated integrals describing the detailed vascular geometry, a capillary bleed-off distribution function and parameters describing the shunting of blood to the cutaneous layer. Representative heat transfer results for typical physiological conditions are presented.

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Journal ArticleDOI

The role of porous media in modeling flow and heat transfer in biological tissues

TL;DR: The main concepts studied in this review are transport in porous media using mass diffusion and different convective flow models such as Darcy and the Brinkman models as mentioned in this paper, and energy transport in tissues is also analyzed.
Journal Article

Microvascular architecture in a mammary carcinoma: branching patterns and vessel dimensions.

TL;DR: Solid tumor vascular architecture, while exhibiting several features that are similar to those observed innormal tissues, has others that are not commonly seen in normal tissues, thus reducing the efficacy of present day cancer therapies.
Journal ArticleDOI

Recent developments in modeling heat transfer in blood perfused tissues

TL;DR: The present review compares and contrasts several of the new bio-heat transfer models, emphasizing the problematics of their experimental validation, in the absence of measuring equipment capable of reliable evaluation of tissue properties and their variations that occur in the spatial scale of blood vessels with diameters less than about 0.2 mm.
Book ChapterDOI

Mathematical Models of Bioheat Transfer

TL;DR: The characteristics of the original Pennes theory are still being used today in bioheat transfer research, along with the current understanding and future prospects for advances in bio heat transfer via a bioheatTransfer equation are discussed.
Journal ArticleDOI

Mathematical Modeling of Skin Bioheat Transfer

TL;DR: It is proposed that a detailed understanding of the coupled biological-mechanical response under thermal agitation will contribute to the design, characterization, and optimization of strategies for delivering better treatment.
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