Journal ArticleDOI
Thermal decomposition mechanism of tenofovir disoproxil fumarate
TLDR
In this article, thermal decomposition processes of TDF were measured with thermogravimetry, differential scanning calorimetry and thermal gating analysis coupled with Fourier transform infrared spectroscopy, and molecular bond orders were calculated using an ab initio method from the GAMESS program of quantum chemistry.Abstract:
Tenofovir disoproxil fumarate (TDF) is an antiretroviral medication widely used to prevent and treat HIV/AIDS and to treat chronic hepatitis B. In this paper, thermal decomposition processes of TDF were measured with thermogravimetry, differential scanning calorimetry and thermogravimetric analysis coupled with Fourier transform infrared spectroscopy. The IR spectra, high-performance liquid chromatography and liquid chromatography mass spectrometry of TDF and the residues of its thermal decomposition at various temperatures were determined. The molecular bond orders were calculated using an ab initio method from the GAMESS program of quantum chemistry. The mechanism of thermal decomposition was discussed. The results indicated that the thermal decomposition of TDF is a three-step process, the initial step of thermal decomposition of TDF is the decomposition of carboxylic ester, the first stage mainly is the decomposition of the phosphoric disoproxil section, and the second stage mainly is the decomposition of the tenofovir section and partially goes through adenine stage. The initial decomposition temperature in either nitrogen or air is 138 °C, and the thermal stability of TDF is not very good under routine temperature.read more
Citations
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Electrospun fibers for vaginal administration of tenofovir disoproxil fumarate and emtricitabine in the context of topical pre-exposure prophylaxis
Rute Nunes,Sarah Bogas,Maria João Faria,Hugo Gonçalves,Marlene Lúcio,T. M. R. Viseu,Bruno Sarmento,José Neves +7 more
TL;DR: In this article, electrospun fibers based on polycaprolactone (PCL) or liposomes associated to poly(vinyl alcohol) (liposomes-in-PVA fibers) were tested for morphological and physicochemical properties using scanning electron microscopy, differential scanning calorimetry and X-ray diffractometry.
Journal ArticleDOI
Determination of enantiomeric impurity of tenofovir disoproxil fumarate on a cellulose tris(3,5-dichlorophenyl-carbamate) chiral stationary phase and the characterization of its related substances.
Bao-Tan Nguyen,Thi-Anh-Tuyet Le,Xuan-Lan Mai,Thi Ngoc Van Nguyen,Thanh Dung Phan,Jong-Seong Kang,Kyeong Ho Kim +6 more
TL;DR: In this paper, a simple and reliable high-performance liquid chromatography method was developed to determine the enantiomeric impurity of tenofovir disoproxil fumarate, commonly used for the treatment of human immunodeficiency virus and hepatitis B.
Journal ArticleDOI
Tryptophan methyl ester: a proposal of the thermal decomposition mechanism
A. Justino,Ana Carina Sobral Carvalho,L. G. de Vasconcelos,B. M. Gai,André Luiz Agnes Stein,Adriano Buzutti de Siqueira +5 more
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Modeling of Tenofovir Disoproxil Fumarate decontamination using sodium alginate-encapsulated activated carbon: Molecular Dynamics, Monte Carlo and Density Functional Theory
S. Ajebli,G. Kaichouh,Mariam Khachani,H. Babas,Miloud El Karbane,Zaki Safi,Avdullah Berisha,Valbonë Mehmeti,Ismail Warad,Abdelkader Zarrouk,A. Bellaouchou +10 more
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Coupled and Simultaneous Thermal Analysis Techniques in the Study of Pharmaceuticals
Marek Wesolowski,Edyta Leyk +1 more
TL;DR: In this article , the design of coupled thermogravimetry (TG) with Fourier transform infrared spectroscopy (FTIR), TG with mass spectrometry (MS) and TG with gas chromatography/mass spectrometer (GC/MS) systems and the principles of measurement are discussed.
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