Journal ArticleDOI
Thin-film microbiosensors for glucose-lactate monitoring
Gerhard Jobst,Isabella Moser,Mehdi Varahram,P. Svasek,Elmar Aschauer,Zlatko Trajanoski,Paul Wach,Peter Kotanko,Falko Skrabal,Gerald Urban +9 more
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TLDR
A miniaturized device for simultaneous measurement of glucose and lactate levels was produced by means of photopatterning of enzyme-containing photosensitive membrane precursors and subcutaneous measurements of glucose levels in pigs were close to the corresponding blood levels obtained without in vivo calibration.Abstract:
A miniaturized device for simultaneous measurement of glucose and lactate levels was produced by means of photopatterning of enzyme-containing photosensitive membrane precursors. This device shows no cross-talk and a lifetime for both the glucose and the lactate sensors of more than 2 weeks when continuously operated in undiluted bovine serum. Linear response ranges of up to 40 mM for glucose and 25 mM for l-lactate, in combination with 95% response times of 0.98 with respect to laboratory techniques. Subcutaneous measurements of glucose levels in pigs were close to the corresponding blood levels obtained without in vivo calibration.read more
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Hydrogels in Biology and Medicine: From Molecular Principles to Bionanotechnology†
TL;DR: This work highlights recent developments in engineering uncrosslinked and crosslinked hydrophilic polymers for biomedical and biological applications and shows how such systems' intelligent behavior can be used in sensors, microarrays, and imaging.
Journal ArticleDOI
Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis
Wei Gao,Wei Gao,Sam Emaminejad,Sam Emaminejad,Sam Emaminejad,Hnin Yin Yin Nyein,Hnin Yin Yin Nyein,Samyuktha Challa,Kevin Chen,Kevin Chen,Austin J Peck,Hossain M. Fahad,Hossain M. Fahad,Hiroki Ota,Hiroki Ota,Hiroshi Shiraki,Hiroshi Shiraki,Daisuke Kiriya,Daisuke Kiriya,Der Hsien Lien,George A. Brooks,Ronald W. Davis,Ali Javey,Ali Javey +23 more
TL;DR: This work bridges the technological gap between signal transduction, conditioning, processing and wireless transmission in wearable biosensors by merging plastic-based sensors that interface with the skin with silicon integrated circuits consolidated on a flexible circuit board for complex signal processing.
Patent
Analyte Monitoring Device And Methods Of Use
James Say,Michael F. Tomasco,Adam Heller,Yoram Gal,Behrad Aria,Ephraim Heller,Phillip John Plante,Mark S. Vreeke,Keith A. Friedman,Fredric C. Colman +9 more
TL;DR: An analyte monitor includes a sensor, a sensor control unit, and a display unit as discussed by the authors, which is used to display an indication of a level of an analyte, based on the data obtained using the sensor.
Patent
Transcutaneous analyte sensor
TL;DR: In this paper, the present paper relates to systems and methods for transcutaneous measurement of glucose in a host, and the present invention relates to the system and method for measuring an analyte in the host.
Patent
Subcutaneous glucose electrode
Adam Heller,Michael V. Pishko +1 more
TL;DR: In this article, a small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described, which is designed to allow "one-point" in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood.
References
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Journal ArticleDOI
Cortical evoked potential and extracellular K+ and H+ at critical levels of brain ischemia.
TL;DR: The hypothesis that electrical failure in ischemia may be directly associated with a massive release of intracellular K+ or with a critical degree of extracellular acidosis is tested and the concept of an ischemic penumbra during which the neurons remain structurally intact but functionally inactive is supported.
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Performance of subcutaneously implanted needle-type glucose sensors employing a novel trilayer coating
TL;DR: A miniature, needle-type glucose sensor based on a new trilayer membrane configuration has been prepared and evaluated both in vitro and in vivo, and remained functional after 1 week of implantation, but failed after 2 weeks due to degradation of the reference electrode.
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Pen-sized digital 30-second blood glucose meter
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Evaluation of a novel point-of-care system, the i-STAT portable clinical analyzer.
Katherine Erickson,Peter Wilding +1 more
TL;DR: The i-STAT Portable Clinical Analyzer system was evaluated for precision, accuracy, and utility in emergency department and stat laboratory settings and mean hematocrit values significantly differed between the PCA and the Coulter ST, apparently because of different calibration procedures.
Journal ArticleDOI
Towards continuous glucose monitoring in vivo evaluation of a miniaturized glucose sensor implanted for several days in rat subcutaneous tissue
D. Moatti-Sirat,Frédérique Capron,Vincent Poitout,Gérard Reach,Dilbir S. Bindra,Yanan Zhang,George S. Wilson,Daniel R. Thévenot +7 more
TL;DR: It is concluded that this miniaturized glucose sensor, whose size makes it easily implanted, works for at least ten days after implantation into rat subcutaneous tissue.