Journal ArticleDOI
Thrombosis in pregnancy: maternal and fetal issues
TLDR
The high prevalence of thrombophilic defects in the population, the association of defects with maternal and fetal disorders, and special considerations for management make it essential for obstetricians to understand this area.About:
This article is published in The Lancet.The article was published on 1999-04-10. It has received 519 citations till now. The article focuses on the topics: Maternal death & Miscarriage.read more
Citations
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Pre-eclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysis
TL;DR: A history of pre-eclampsia should be considered when evaluating risk of cardiovascular disease in women, and this association might reflect a common cause for pre- eClampsia and cardiovascular disease, or an effect ofPre-e Clampsia on disease development, or both.
Journal ArticleDOI
Venous thromboembolism, thrombophilia, antithrombotic therapy, and pregnancy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition).
TL;DR: In this paper, the management of venous thromboembolism (VTE) and thrombophilia, as well as the use of antithrombotic agents, during pregnancy is discussed.
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Pregnancy complications and maternal cardiovascular risk: opportunities for intervention and screening?
Naveed Sattar,Ian A. Greer +1 more
TL;DR: Evidence is increasingly linking the maternal vascular, metabolic, and inflammatory complications of pregnancy with an increased risk of vascular disease in later life (table), and this article summarises the evidence, notes important areas for further research, and discusses potential practical implications.
American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
TL;DR: Hirsh et al. as discussed by the authors published the 8th edition of the Clinical of Chest Physicians Evidence-Based Parenteral Anticoagulants (8th Edition) Clinical Guidelines, 2008.
Journal ArticleDOI
Subclassification of Preeclampsia
TL;DR: A first step would be to subdivide preeclampsia into early‐onset disease (< 34 + 0 weeks') and late onset disease (> 34 +0 weeks').
References
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A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis.
TL;DR: An association was found between the presence of the 20210 A allele and elevated prothrombin levels and Elevated pro thirdrombin itself also was found to be a risk factor for venous thrombosis.
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Heparin-Induced Thrombocytopenia in Patients Treated with Low-Molecular-Weight Heparin or Unfractionated Heparin
Theodore E. Warkentin,Mark Levine,Jack Hirsh,Peter Horsewood,Robin S. Roberts,Michael Gent,John G. Kelton +6 more
TL;DR: Daily platelet counts in 665 patients in a randomized, double-blind clinical trial comparing unfractionated heparin with low-molecular-weight hepar in as prophylaxis after hip surgery revealed heparIn-induced thrombocytopenia, associated thromBotic events, and heParin-dependent IgG antibodies are more common in patients treated with unfractionate heparine than in those treated with low,molecules-weight He
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Venous thrombosis: a multicausal disease.
TL;DR: The risk factors for venous thrombosis differ from those for arterial vascular disease, particularly the role of coagulation abnormalities, and the resultant gene-gene and gene-environment interactions between risk factors are the key to the understanding of why a certain person develops thromBosis at a specific point in time.
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Increased frequency of genetic thrombophilia in women with complications of pregnancy.
Michael J. Kupferminc,Amiram Eldor,Nitzan Steinman,Ariel Many,Amiram Bar-Am,Ariel J. Jaffa,Gideon Fait,Joseph B. Lessing +7 more
TL;DR: Women with serious obstetrical complications have an increased incidence of mutations predisposing them to thrombosis and other inherited and acquired forms ofThrombophilia.
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Randomised controlled trial of aspirin and aspirin plus heparin in pregnant women with recurrent miscarriage associated with phospholipid antibodies (or antiphospholipid antibodies)
TL;DR: The prognosis for pregnancies in women with recurrent miscarriage associated with phospholipid antibodies is poor but this randomised controlled trial found that the prognosis improved with low dose aspirin and was further improved with the addition of low dose heparin to the aspirin.