Journal ArticleDOI
Thyroxine increases nerve growth factor concentration in adult mouse brain
TLDR
Thyroxine administration significantly increased the concentration of nerve growth factor in all three brain areas compared to control values, whereas propylthiouracil was without effect, suggesting that thyroid hormones stimulate nerve growthFactor synthesis in the mature central nervous system.Abstract:
The effects of thyroxine and propylthiouracil on nerve growth factor concentrations in cerebral cortex, cerebellum, and brainstem of adult male mice were assessed by using a sensitive radioimmunoassay for the beta-subunit of mouse nerve growth factor. Thyroxine administration significantly increased the concentration of nerve growth factor in all three brain areas compared to control values, whereas propylthiouracil was without effect. These results suggest that thyroid hormones stimulate nerve growth factor synthesis in the mature central nervous system, and raise the possibility that the influence of thyroid hormones on central nervous system development might be mediated or influenced by nerve growth factor.read more
Citations
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Journal ArticleDOI
The role of thyroid hormones in prenatal and neonatal neurological development--current perspectives.
TL;DR: It now appears that fetal thyroid hormones play an essential role in fetal brain development, and as some placental transport of thyroid hormones has been shown to occur, it is possible that maternal thyroid hormones might influence Fetal brain development.
Journal ArticleDOI
Thyroid development and disorders of thyroid function in the newborn.
Delbert A. Fisher,Alan H. Klein +1 more
TL;DR: A large number of the newborns diagnosed with congenital hypothyroidism have had their thyroid glands removed, leading to concerns of a down-regulation of the immune system and an increased risk of serious complications.
Journal ArticleDOI
The expression, localization and functional significance of β-nerve growth factor in the central nervous system
Scott R. Whittemore,Åke Seiger +1 more
TL;DR: NGF and central catecholaminergic neuronal function, NGF-induced alteration in adrenergic CNS function, and retrograde transport of NGF in Adrenergic pathways are studied.
Book ChapterDOI
Thyroid Hormones and Brain Development
TL;DR: The identification of the gene network regulated by thyroid hormone during brain development, the elucidation of the mechanism of regulation and the clarification of the physiological roles of the regulated genes remain major goals for future studies.
Journal ArticleDOI
Corneal nerves in health and disease
TL;DR: Evidence-based treatment of neurotrophic corneal diseases includes using neuroregenerative (blood component-based and neurotrophic factors), neuroprotective, and ensconcing (bandage contact lens and amniotic membrane) strategies and avoiding anti-inflammatory therapies, such as cyclosporine and corticosteroids.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI
Characterization and isolation of proteolytically modified nerve growth factor
Journal ArticleDOI
The retrograde axonal transport of nerve growth factor
TL;DR: It is concluded that the retrograde axonal transport of NGF, which was estimated to take place at a rate of about 2.5 mm/h, depends on a colchicine-sensitive mechanism as does the orthograde rapid axonal transports, however, the uptake of N GF may not only take place from the nerve terminals but also from the preterminal parts, as has been shown in other studies with horseradish peroxidase.
Journal ArticleDOI
The effects of early hypo- and hyperthyroidism on the development of rat cerebellar cortex. I. Cell proliferation and differentiation.
Jean L. Nicholson,Joseph Altman +1 more
TL;DR: The role played by thyroid hormone in the initiation of cell differentiation in the central nervous system is discussed and mechanisms of differentiation of cells derived from the external granular layer are discussed.
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The effects of early hypo- and hyperthyroidism on the development of rat cerebellar cortex. I. Cell proliferation and differentiation.
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