TNF-α Gene Polymorphisms and Excessive Daytime Sleepiness In Pediatric Obstructive Sleep Apnea
Abdelnaby Khalyfa,Abdelnaby Khalyfa,Laura D. Serpero,Leila Kheirandish-Gozal,Leila Kheirandish-Gozal,Oscar Sans Capdevila,Oscar Sans Capdevila,David Gozal,David Gozal +8 more
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TLDR
TNF-α levels are increased in a subset of children with OSA, particularly among those harboring the TNF-β single nucleotide polymorphism, particularly -308G.About:
This article is published in The Journal of Pediatrics.The article was published on 2011-01-01 and is currently open access. It has received 80 citations till now. The article focuses on the topics: Epworth Sleepiness Scale & Excessive daytime sleepiness.read more
Citations
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Journal ArticleDOI
Diagnosis and Management of Childhood Obstructive Sleep Apnea Syndrome
Sally L. Davidson Ward,Christopher Lehmann,Jacqueline Jones,Michael S. Schechter,Stephen H. Sheldon,L. Marcus,Lee J. Brooks,Kari A. Draper,David Gozal,David Gozal,Ann Carol +10 more
TL;DR: This practice guideline focuses on uncomplicated childhood OSAS, that is, OSAS associated with adenotonsillar hypertrophy and/or obesity in an otherwise healthy child who is being treated in the primary care setting.
Journal ArticleDOI
Obstructive sleep disordered breathing in 2- to 18-year-old children: diagnosis and management.
Athanasios G. Kaditis,Maria Luz Alonso Alvarez,An Boudewyns,Emmanouel I. Alexopoulos,Refika Ersu,Koen F. M. Joosten,Helena Larramona,Silvia Miano,Indra Narang,Ha Trang,Marina Tsaoussoglou,Nele Vandenbussche,Maria Pia Villa,Dick A. van Waardenburg,Silke Anna Theresa Weber,Stijn Verhulst +15 more
TL;DR: This document summarises the conclusions of a European Respiratory Society Task Force on the diagnosis and management of obstructive sleep disordered breathing (SDB) in childhood and refers to children aged 2–18 years.
Journal ArticleDOI
Sleep duration, cardiovascular disease, and proinflammatory biomarkers.
TL;DR: This review summarizes what is known from experimental and cross-sectional studies about the association between sleep duration, cardiovascular disease, and proinflammatory biomarkers and details specific findings related to specific molecules.
Journal ArticleDOI
Obstructive sleep apnea in children: a critical update.
TL;DR: The major concepts regarding the pathophysiology of OSA, its morbidity, diagnosis, and treatment are delineated.
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Obstructive Sleep Apnea and Inflammation: Proof of Concept Based on Two Illustrative Cytokines.
TL;DR: The published links between OSAS and systemic inflammation will be critically reviewed, with special focus on the pro-inflammatory cytokines tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6), since these constitute classical prototypes of the large spectrum of inflammatory molecules that have been explored in OSAS patients.
References
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A new method for measuring daytime sleepiness: the Epworth sleepiness scale.
TL;DR: The development and use of a new scale, the Epworth sleepiness scale (ESS), is described, which is a simple, self-administered questionnaire which is shown to provide a measurement of the subject's general level of daytime sleepiness.
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A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects.
TL;DR: Techniques of recording, scoring, and doubtful records are carefully considered, and Recommendations for abbreviations, types of pictorial representation, order of polygraphic tracings are suggested.