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Showing papers in "The Journal of Pediatrics in 2011"


Journal ArticleDOI
TL;DR: A 12-year-old boy currently is followed by multiple sub-specialists for problems caused by the chromosome 22q11.2 deletion syndrome (22q11DS) and has mild dysmorphic facial features of a boy aged 11 years with 22q 11.2DS.

483 citations


Journal ArticleDOI
TL;DR: In this article, the outcomes after prolonged empirical antibiotic administration to premature infants in the first week of life were investigated, and concluding subsequent late onset sepsis (LOS), necrotizing enterocolitis (NEC), and death.

464 citations


Journal ArticleDOI
TL;DR: In this article, the authors examined tracking and predictiveness of childhood lipid levels, blood pressure, and body mass index for risk profile in adulthood and the best age to measure the childhood risk factor levels.

430 citations


Journal ArticleDOI
TL;DR: Language ability is reduced in VPT/VLBW children, and when considering only school-aged children, this reduction is still present, suggesting that their difficulty appears to be ongoing.

310 citations


Journal ArticleDOI
TL;DR: In this paper, the duration of antibiotic exposure is associated with an increased risk of necrotizing enterocolitis among infants without prior sepsis, while exposure for >10 days resulted in a nearly threefold increase in the risk of developing NEC.

307 citations


Journal ArticleDOI
TL;DR: Primary steroid therapy did not improve coronary outcomes in patients prospectively classified as being at high-risk for IVIG resistance, and risk-scoring systems from Japan have good specificity but low sensitivity for predictingIVIG resistance in a North American cohort.

303 citations



Journal ArticleDOI
TL;DR: The Beighton score, when goniometry is used, is a valid instrument to measure generalized joint mobility in school-age children 6 to 12 years and no extra items are needed to improve the scale.

299 citations


Journal ArticleDOI
TL;DR: In this paper, the feasibility of implementing a broadband screen at the 1-year check-up to detect cases of autism spectrum disorders (ASD), language delay (LD), and developmental delay (DD) was evaluated.

228 citations


Journal ArticleDOI
TL;DR: Microflora diversity settled progressively in very preterm infants and was associated with the digestive tolerance profile, and measures that may improve microflora could have beneficial effects on digestive tolerance and growth.

202 citations


Journal ArticleDOI
TL;DR: It is concluded that PRBC-related NEC exists and the convergence at 31 weeks postconceptual age approximates the age of presentation of other O(2) delivery and neovascularization syndromes, suggesting a link to a generalized systemic maturational mechanism.

Journal ArticleDOI
TL;DR: It is suggested that although hypothermia is unequivocally a promising therapy for HIE, a substantial proportion of infants still suffer from death or disability despite treatment, and should lead to an overall measure of caution in applying the new therapy of hypotheria indiscriminately for all cases of HIE.

Journal ArticleDOI
TL;DR: The results indicate that hypovitaminosis D is frequent in children with asthma living in a Mediterranean country and in those children, lower levels of vitamin D are associated with reduced asthma control.

Journal ArticleDOI
TL;DR: Altered postnatal fatty acid levels in premature infants are associated with an increased risk of chronic lung disease (CLD) and late-onset sepsis.

Journal ArticleDOI
TL;DR: Plasma and urine NGAL thresholds significantly increased in patients with AKI at 2 hours after CPB and remained elevated at all points, with 2-hour NGAL the earliest, strongest predictor of AKI.

Journal ArticleDOI
TL;DR: Preschoolers' cumulative screen time exceeds recommendations and most previous estimates and Efforts to decrease screen time in homes and home-based child care settings are needed.

Journal ArticleDOI
TL;DR: Hospitalized patients who used a structured clinical program for children with medical complexity experienced lengthy hospitalizations with high early readmission rates, and reducing hospital readmission may be one potential strategy for decreasing inpatient expenditures in this group of children with high resource utilization.

Journal ArticleDOI
TL;DR: Renal function and serum troughs in children receiving vancomycin, especially those with targeted troughs of ≥ 15 mg/L, in intensive care, and receiving furosemide, should be closely monitored.

Journal ArticleDOI
TL;DR: CP incidence and severity decreased from 1990-1993 onward, which could be attributed to a reduction of 93% in severe c-PVL.

Journal ArticleDOI
TL;DR: The primary reliance on serum food-specific IgE testing to determine the need for a food elimination diet is not sufficient, especially in children with atopic dermatitis, and oral food challenges may be indicated to confirm food allergy status.

Journal ArticleDOI
TL;DR: It is demonstrated that race and sex differences in telomere length have already emerged during adolescence, adiposity and adipokines are not associated with telomeres length at this age, and the antiaging effect of vigorous physical activity may begin in youth, especially in girls.

Journal ArticleDOI
TL;DR: Patients with IVig-resistant Kawasaki disease whose first re-treatment was with infliximab, compared with IVIG, had faster resolution of fever and fewer days of hospitalization.

Journal ArticleDOI
TL;DR: Both moderate and early preterm infants had more frequent problems with fine motor, communication, and personal-social functioning compared with full-term infants, and Socioeconomic status, small for gestational age status, and sex were associated with abnormal ASQ scores in moderate pre term infants.

Journal ArticleDOI
TL;DR: In healthy adolescent males and females, bone mass and bone density at skeletal maturity are inversely related to the timing of puberty, as observed in the Bone Mineral Density in Childhood Study.

Journal ArticleDOI
TL;DR: ALF in young infants presents unique diagnostic considerations and spontaneous survival is better than previously thought, and Liver transplantation provides an additional option for care.

Journal ArticleDOI
TL;DR: Exposure to maternal diabetes in utero accelerates BMI growth in late childhood, thus increasing long-term obesity risk, according to a diverse cohort of youth.

Journal ArticleDOI
TL;DR: Hypocarbia is associated with poor outcome after hypoxic-ischemic encephalopathy, and death/disability increased with greater cumulative exposure to PCO(2) <35 mm Hg.

Journal ArticleDOI
TL;DR: Shorter and longer sleep durations are associated with decreased insulin sensitivity in adolescents, and the association between shorter sleep duration and HOMA was appreciably attenuated, but the association with longer sleep persisted.

Journal ArticleDOI
TL;DR: ACS exposure improved survival of extremely preterm infants and should be considered for threatened preterm birth at 22 to 23 weeks of gestation.

Journal ArticleDOI
TL;DR: In long-term follow-up, most patients with PFAPA experienced spontaneous symptom resolution without sequelae, and patients with persistent symptoms had episodes of shorter duration and reduced frequency.