Journal ArticleDOI
Topical capsaicin administration protects against trinitrobenzene sulfonic acid-induced colitis in the rat
Cristina Goso,Stefano Evangelista,Manuela Tramontana,Stefano Manzini,Peter M. Blumberg,Arpad Szallasi +5 more
Reads0
Chats0
TLDR
It is concluded that acute Capsaicin administration protects against the ulcerative action of trinitrobenzene sulfonic acid, most likely via the release of protective neuropeptides from capsaicin-sensitive nerve endings.About:
This article is published in European Journal of Pharmacology.The article was published on 1993-11-09. It has received 66 citations till now. The article focuses on the topics: Resiniferatoxin & Capsazepine.read more
Citations
More filters
Journal Article
Vanilloid (Capsaicin) Receptors and Mechanisms
Arpad Szallasi,Peter M. Blumberg +1 more
TL;DR: This paper focuses on hot pepper, which is eaten on a daily basis by an estimated one-quarter of the world’s population and has potential to be a biological target for regenerative medicine.
Journal ArticleDOI
Transient Receptor Potential Channels as Drug Targets: From the Science of Basic Research to the Art of Medicine
Bernd Nilius,Arpad Szallasi +1 more
TL;DR: An overview of the functional properties of mammalian TRP channels is given, their roles in acquired and hereditary diseases are described, and their potential as drug targets for therapeutic intervention is discussed.
Journal ArticleDOI
Transient receptor potential (TRP) channels: a clinical perspective.
Yosuke Kaneko,Arpad Szallasi +1 more
TL;DR: There has been a recent upsurge in the amount of work that expands TRP channel drug discovery efforts into new disease areas such as asthma, cancer, anxiety, cardiac hypertrophy, as well as obesity and metabolic disorders.
Journal ArticleDOI
Up-regulation of anandamide levels as an endogenous mechanism and a pharmacological strategy to limit colon inflammation
Giuseppe D'Argenio,Marta Valenti,Giuseppe Scaglione,V. Cosenza,Italo Sorrentini,Vincenzo Di Marzo +5 more
TL;DR: Anandamide is elevated in the inflamed colon of patients with ulcerative colitis, as well as in animal models of IBDs, to control inflammation, and elevation of its levels with inhibitors of its cellular reuptake might be used in the treatment of I BDs.
Journal ArticleDOI
The vanilloid (capsaicin) receptor: Receptor types and species differences
TL;DR: Differences in receptor binding along with the pharmacokinetical differences in tissue equilibration and in plasma binding may form a rational basis to explain the peculiar spectrum of actions of RTX.
References
More filters
Journal ArticleDOI
Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction.
TL;DR: The analysis described shows K I does not equal I 50 when competitive inhibition kinetics apply; however, K I is equal to I 50 under conditions of either noncompetitive or uncompetitive kinetics.
Journal Article
Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons.
Journal ArticleDOI
Local effector functions of capsaicin-sensitive sensory nerve endings : involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides
TL;DR: Etude du mecanisme d'action des neurones sensoriels et des fonctions de leurs effecteurs locaux en reponse a differents stimuli, au niveau des tissus directement en contact avec l'environnement exterieur.
Journal Article
The neuropharmacology of capsaicin: review of some recent observations.
Journal ArticleDOI
Capsazepine: a competitive antagonist of the sensory neurone excitant capsaicin.
Stuart Bevan,S. Hothi,Glyn Hughes,Iain F. James,Humphrey P. Rang,Kirti Shah,Walpole Christopher,J.C. Yeats +7 more
TL;DR: The present study shows the capsazepine acts as a competitive antagonist of capsaicin, with significant effects on the efflux of 86Rb+ from cultured DRG neurones evoked either by depolarization with high (50 mm) K+ solutions or by acidification of the external medium to pH 5.6.