Journal ArticleDOI
Total synthesis of (.+-.)-5,6-oxido-7,9-trans,11,14-cis-eicosapentaenoic acid, a possible precursor of SRSA
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This article is published in Journal of the American Chemical Society.The article was published on 1979-10-01. It has received 69 citations till now. The article focuses on the topics: Eicosapentaenoic acid & Total synthesis.read more
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Journal ArticleDOI
Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation
TL;DR: Leukotrienes C4, D4, and E4, which are released from the lung tissue of asthmatic subjects exposed to specific allergens, seem to play a pathophysiological role in immediate hypersensitivity reactions.
Journal ArticleDOI
Recent advances in the preparation and synthetic applications of oxiranes
Journal ArticleDOI
Structure of leukotriene C. Identification of the amino acid part.
TL;DR: The substituent of Leukotriene C, a “Slow Reacting Substance” from mouse mast cell tumors, was earlier shown to be a derivative of 5-hydroxy-7,9,11,14-eicosatetraenoic acid with a cysteine containing substitution in thioether linkage at C-6, has been identified as γ-glutamylcysteinylglycine (glutathione).
Journal ArticleDOI
Leukotrienes and Slow Reacting Substance of Anaphylaxis (SRS‐A)
TL;DR: It was shown that perfused segments of human lung from asthmatic patients produced SRS-A after treatment with birch or timothy pollen, and addition of allergens to Bronchial rings from these patients resulted in a prolonged contraction of the bronchial muscle and release of S RS-A.
Journal ArticleDOI
Slow reacting substances (SRSs): the structure identification of SRSs from rat basophil leukaemia (RBL-1) cells.
TL;DR: The characteristic triene chromophore which was originally identified in immunologically generated SRS-A is present in RBL-l SRS, and the structure is determined as the thio-substituted dipeptide, 5-hydroxy-6-cysteinylglycinyl-7,9,11,14-eicosatetraenoic acid.
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