Journal ArticleDOI
Total synthesis of an enantiomeric pair of FR900482. 2. Syntheses of the aromatic and the optically active aliphatic segments
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TLDR
In this paper, the synthesis of the aromatic segment 4 was achieved starting from commercially available 5-hydroxyisophthalic acid (6) by utilizing Claisen rearrangement of 9, bromolactonization of 12, and modified Curtius rearrangements of 16 as the key steps.About:
This article is published in Tetrahedron.The article was published on 1997-07-28. It has received 37 citations till now. The article focuses on the topics: Curtius rearrangement & Azide.read more
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Mitomycinoid Alkaloids: Mechanism of Action, Biosynthesis, Total Syntheses, and Synthetic Approaches
TL;DR: It was shown that monoalkylation and not cross-linking was the major adduct found when an FR-900482 derivative was incubated with nucleosomes, which could suggest alternate modes of action of this family of natural products in the context of cellular chromatin.
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Impact of copper-catalyzed cross-coupling reactions in natural product synthesis: the emergence of new retrosynthetic paradigms.
TL;DR: The impact of copper-catalyzed cross-coupling reactions in natural product synthesis will be overviewed with an emphasis on the evolution of strategies due to copper catalysis, mostly by comparison with alternative tactics and their relative efficiencies.
Journal ArticleDOI
Synthesis of Polycyclic Benzofused Nitrogen Heterocycles via a Tandem Ynamide Benzannulation/Ring Closing Metathesis Strategy. Application in a Formal Total Synthesis of (+)-FR900482
TL;DR: A two-stage "tandem strategy" for the synthesis of benzofused nitrogen heterocycles is described that is particularly useful for the construction of systems with a high level of substitution on the benzenoid ring.
Journal ArticleDOI
Novel syntheses of bridge-containing organic compounds.
TL;DR: Reactions in Synthesis of FR66979 and FR900482 1732 8.1.
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Development of a Flexible Strategy towards FR900482 and the Mitomycins
TL;DR: This work envisioned a common synthetic strategy by which both classes could be targeted through assembling the mitomycin skeleton prior to further oxidative functionalization, and achieved this strategy through the synthesis of 7-epi-FR900482, which displayed equal potency relative to the natural product against two human cancer cell lines.
References
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A 2dvEv- bit distributed algorithm for the directed Euler trail problem
Wen-Huei Chen,Chuan Yi Tang +1 more
TL;DR: The algorithm can be used as a building block for solving other distributed graph problems, and can be slightly modified to run on a strongly-connected diagraph for generating the existent Euler trail or to report that no Euler trails exist.
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.alpha.-Methoxy-.alpha.-trifluoromethylphenylacetic acid, a versatile reagent for the determination of enantiomeric composition of alcohols and amines
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Catalytic asymmetric epoxidation and kinetic resolution: modified procedures including in situ derivatization
TL;DR: The use of 3A or 4A molecular sieves substantially increases the scope of the titanium(IV)-catalyzed asymmetric epoxidation of primary allylic alcohols as mentioned in this paper.