Journal ArticleDOI
Total synthesis of erythromycins. 5. Total synthesis of erythronolide A
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This article is published in Journal of the American Chemical Society.The article was published on 1979-09-01. It has received 142 citations till now. The article focuses on the topics: Total synthesis.read more
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Antibacterial Natural Products in Medicinal Chemistry—Exodus or Revival?
TL;DR: Significant contributions from industrial and academic groups highlight the arduous but rewarding path from natural products to drugs, as well as principle modification types for natural products, which are discussed herein.
Journal ArticleDOI
Macrolactonizations in the Total Synthesis of Natural Products
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Natural Products as Platforms To Overcome Antibiotic Resistance
TL;DR: Synthetic approaches aiming to reengineer natural products into potent antibiotics, as well as narrow-spectrum pathogen-specific antibiotics, are analyzed given new insights into the implications of disrupting the microbiome.
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Chemical consequences of conformation in macrocyclic compounds
W. Clark Still,Igor Galynker +1 more
TL;DR: In this paper, the conformational properties of medium and large-ring organic molecules have profound consequences on the stereochemical course of their chemical reactions, and the diastereomeric composition of the products was determined.