Journal ArticleDOI
Translocation t(11;19)(q21;p13.1) as the sole chromosome abnormality in a cystadenolymphoma (Warthin's tumor) of the parotid gland.
TLDR
A reciprocal balanced translocation t(11;19)(q21;p13.1) as the sole clonal abnormality was found in the majority of metaphases, and the proliferation of epithelial cells was observed in the cultures, which should stimulate further efforts for cytogenetic investigations of the epithelial part.About:
This article is published in Cancer Genetics and Cytogenetics.The article was published on 1988-10-01. It has received 64 citations till now. The article focuses on the topics: Warthin's tumor & Parotid gland.read more
Citations
More filters
Journal ArticleDOI
Advances in salivary gland pathology.
W Cheuk,John K.C. Chan +1 more
TL;DR: This review summarizes the new findings on salivary gland pathology under the following categories: immunohistochemistry; molecular genetics; newly recognized tumour types; known tumour entities with new findings; and progression of salivARY gland tumours.
Journal ArticleDOI
MECT1-MAML2 fusion transcript defines a favorable subset of mucoepidermoid carcinoma
Mitsukuni Okabe,Satoru Miyabe,Satoru Miyabe,Hitoshi Nagatsuka,Akihiro Terada,Nobuhiro Hanai,Motoo Yokoi,Kazuo Shimozato,Tadaaki Eimoto,Shigeo Nakamura,Noriyuki Nagai,Yasuhisa Hasegawa,Hiroshi Inagaki +12 more
TL;DR: The MECT1-MAML2 fusion transcript is associated with a distinct mucoepidermoid carcinoma subset that exhibits favorable clinicopathologic features and an indolent clinical course and emerged as an independent prognostic factor for longer overall survival on multivariate analysis.
Journal ArticleDOI
Salivary mucoepidermoid carcinoma: revisited
TL;DR: These new schemes, the histologic variants of MEC, and the ancillary methods that allow for further stratification of patients with MEC are described, especially for patients with grade 2 tumors, which have a variable and unpredictable clinical course.
Journal ArticleDOI
CRTC1/MAML2 fusion transcript in high grade mucoepidermoid carcinomas of salivary and thyroid glands and Warthin's tumors: implications for histogenesis and biologic behavior.
Yamilet Tirado,Michelle D. Williams,Ehab Y. Hanna,Frederic J. Kaye,John G. Batsakis,Adel K. El-Naggar +5 more
TL;DR: It is concluded that the CRTC1/MAML2 transcript may be detected in both low and high grade MEC, that fusion negative tumors may define a subset of biologically aggressive MEC's tumors, that the fusion is present in primary MECs of the thyroid gland and is also detectable in Warthin's tumor, and that a subset that can be targeted for therapeutic intervention.
Journal ArticleDOI
Non‐random chromosome rearrangements in adenoid cystic carcinoma of the salivary glands
TL;DR: A survey of the present findings together with previous results from 15 ACC clearly demonstrates that rearrangements of 6q21‐24 (deletions or translocations in 11 cases), 9p13‐23 (translocations in seven cases), and 17p12‐13 (trans Locations in three cases) are recurrent, and often primary, in ACC, and that the t(6;9)(q 21‐24;p13-23), found in five tumors, is a
References
More filters
Journal ArticleDOI
Report of the committee on chromosome rearrangements in neoplasia and on fragile sites
Journal ArticleDOI
The mixed salivary gland tumor — A normally benign human neoplasm frequently showing specific chromosomal abnormalities
TL;DR: The findings in this case showed that several, possibly many, karyotypic evolutionary pathways exist in pleomorphic adenomas, and in relation to the possible general significance of chromosome changes affecting Nos. 3 and 8.
Journal Article
Cytogenetical observations in 100 human benign pleomorphic adenomas: specificity of the chromosomal aberrations and their relationship to sites of localized oncogenes.
Mark J,Dahlenfors R +1 more
TL;DR: Using short-term cultures, the chromosomes in 19 human benign pleomorphic adenomas were studied by banding methods and it was noteworthy that almost 50% of the abnormal stemlines showed a proximal long-arm rearrangement of No. 8 that could fit with activation of the oncogene c-mos.
Journal ArticleDOI
Rearrangements of chromosome region 12q13----q15 in pleomorphic adenomas of the human salivary gland (PSA).
TL;DR: Nine of 40 pleomorphic salivary gland adenomas showed clonal aberrations of chromosome 12, with a breakpoint at 12q13----q15, which suggests that this type of aberration is a primary change directly involved in the genesis of PSA.
Journal ArticleDOI
Aberrations of chromosome 8 in mixed salivary gland tumors--cytogenetic findings on seven cases.
TL;DR: In an attempt to define the critical segment on chromosome #8, this work has identified the part between 8q11 and 8q13 as the critical region involved in all rearrangements.